Cargando…
Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a debilitating inflammatory respiratory condition that presents with worsening breathing difficulties and it is assumed to be progressive and incurable. As an inflammatory disease, COPD is associated with recruitment of immune cells to lung tissue and...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358145/ https://www.ncbi.nlm.nih.gov/pubmed/34395478 http://dx.doi.org/10.3389/fmed.2021.699427 |
_version_ | 1783737276567650304 |
---|---|
author | Norwitz, Nicholas G. Winwood, Russell Stubbs, Brianna J. D'Agostino, Dominic P. Barnes, Peter J. |
author_facet | Norwitz, Nicholas G. Winwood, Russell Stubbs, Brianna J. D'Agostino, Dominic P. Barnes, Peter J. |
author_sort | Norwitz, Nicholas G. |
collection | PubMed |
description | Chronic Obstructive Pulmonary Disease (COPD) is a debilitating inflammatory respiratory condition that presents with worsening breathing difficulties and it is assumed to be progressive and incurable. As an inflammatory disease, COPD is associated with recruitment of immune cells to lung tissue and increased levels of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and GM-CSF. Low-carbohydrate ketogenic diets have anti-inflammatory properties that could, in theory, improve COPD symptoms and progression. Herein, we report on a 54-year-old patient (C.A.) with COPD who adopted a ketogenic diet (70% calories from fat). Subsequently, C.A. experienced a reduction in inflammatory markers in association with a meaningful improvement in lung function. His inflammatory markers decreased into the normal range and his forced expiratory volume increased by 37.5% relative to its pre-ketogenic diet value. Future research should explore nutritional ketosis and ketogenic diets as possible therapeutic options for individuals with COPD. |
format | Online Article Text |
id | pubmed-8358145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83581452021-08-13 Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease Norwitz, Nicholas G. Winwood, Russell Stubbs, Brianna J. D'Agostino, Dominic P. Barnes, Peter J. Front Med (Lausanne) Medicine Chronic Obstructive Pulmonary Disease (COPD) is a debilitating inflammatory respiratory condition that presents with worsening breathing difficulties and it is assumed to be progressive and incurable. As an inflammatory disease, COPD is associated with recruitment of immune cells to lung tissue and increased levels of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and GM-CSF. Low-carbohydrate ketogenic diets have anti-inflammatory properties that could, in theory, improve COPD symptoms and progression. Herein, we report on a 54-year-old patient (C.A.) with COPD who adopted a ketogenic diet (70% calories from fat). Subsequently, C.A. experienced a reduction in inflammatory markers in association with a meaningful improvement in lung function. His inflammatory markers decreased into the normal range and his forced expiratory volume increased by 37.5% relative to its pre-ketogenic diet value. Future research should explore nutritional ketosis and ketogenic diets as possible therapeutic options for individuals with COPD. Frontiers Media S.A. 2021-07-29 /pmc/articles/PMC8358145/ /pubmed/34395478 http://dx.doi.org/10.3389/fmed.2021.699427 Text en Copyright © 2021 Norwitz, Winwood, Stubbs, D'Agostino and Barnes. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Norwitz, Nicholas G. Winwood, Russell Stubbs, Brianna J. D'Agostino, Dominic P. Barnes, Peter J. Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease |
title | Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease |
title_full | Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease |
title_fullStr | Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease |
title_full_unstemmed | Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease |
title_short | Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease |
title_sort | case report: ketogenic diet is associated with improvements in chronic obstructive pulmonary disease |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358145/ https://www.ncbi.nlm.nih.gov/pubmed/34395478 http://dx.doi.org/10.3389/fmed.2021.699427 |
work_keys_str_mv | AT norwitznicholasg casereportketogenicdietisassociatedwithimprovementsinchronicobstructivepulmonarydisease AT winwoodrussell casereportketogenicdietisassociatedwithimprovementsinchronicobstructivepulmonarydisease AT stubbsbriannaj casereportketogenicdietisassociatedwithimprovementsinchronicobstructivepulmonarydisease AT dagostinodominicp casereportketogenicdietisassociatedwithimprovementsinchronicobstructivepulmonarydisease AT barnespeterj casereportketogenicdietisassociatedwithimprovementsinchronicobstructivepulmonarydisease |