Hypoxia and the Tumor Microenvironment

Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lea...

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Detalles Bibliográficos
Autores principales: Li, Yue, Zhao, Long, Li, Xiao-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Targeting Diagnosis and Treatment in Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358492/
https://www.ncbi.nlm.nih.gov/pubmed/34350796
http://dx.doi.org/10.1177/15330338211036304
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author Li, Yue
Zhao, Long
Li, Xiao-Feng
author_facet Li, Yue
Zhao, Long
Li, Xiao-Feng
author_sort Li, Yue
collection PubMed
description Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.
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spelling pubmed-83584922021-08-13 Hypoxia and the Tumor Microenvironment Li, Yue Zhao, Long Li, Xiao-Feng Technol Cancer Res Treat Targeting Diagnosis and Treatment in Cancer Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment. SAGE Publications 2021-08-05 /pmc/articles/PMC8358492/ /pubmed/34350796 http://dx.doi.org/10.1177/15330338211036304 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Targeting Diagnosis and Treatment in Cancer
Li, Yue
Zhao, Long
Li, Xiao-Feng
Hypoxia and the Tumor Microenvironment
title Hypoxia and the Tumor Microenvironment
title_full Hypoxia and the Tumor Microenvironment
title_fullStr Hypoxia and the Tumor Microenvironment
title_full_unstemmed Hypoxia and the Tumor Microenvironment
title_short Hypoxia and the Tumor Microenvironment
title_sort hypoxia and the tumor microenvironment
topic Targeting Diagnosis and Treatment in Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358492/
https://www.ncbi.nlm.nih.gov/pubmed/34350796
http://dx.doi.org/10.1177/15330338211036304
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AT zhaolong hypoxiaandthetumormicroenvironment
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