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Retiform hemangioendothelioma: a rare lesion of the vulva

Retiform hemangioendothelioma (RH) is a rare borderline-malignant vascular tumor with specific histological characteristics, usually occurring in the limbs and trunk. We report the case of a 63-year-old woman who presented with a painless, oval nodule that had been growing slowly on her left vulva f...

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Autores principales: Zhang, Mingyue, Yin, Xiaojiao, Yao, Weikai, Liu, Ning, Yue, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358529/
https://www.ncbi.nlm.nih.gov/pubmed/34340581
http://dx.doi.org/10.1177/03000605211027783
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author Zhang, Mingyue
Yin, Xiaojiao
Yao, Weikai
Liu, Ning
Yue, Ying
author_facet Zhang, Mingyue
Yin, Xiaojiao
Yao, Weikai
Liu, Ning
Yue, Ying
author_sort Zhang, Mingyue
collection PubMed
description Retiform hemangioendothelioma (RH) is a rare borderline-malignant vascular tumor with specific histological characteristics, usually occurring in the limbs and trunk. We report the case of a 63-year-old woman who presented with a painless, oval nodule that had been growing slowly on her left vulva for 3 years. Magnetic resonance imaging of the pelvic cavity revealed a 4.4- × 2.7- × 1.8-cm cystic lesion in the subcutaneous fat of the left vulva. Resection beyond the macroscopic border was performed. Pathology revealed vascular structures with elongated and narrow arborizing vascular channels that were arranged in a retiform pattern resembling rete testis tissue. Immunohistochemical endothelial staining was positive for CD31, CD34, and Friend leukemia integration-1 (FLI-1). The above features confirmed a diagnosis of RH. There was no local recurrence or metastasis during the 26-month follow-up. RH of the vulva is rare, and its diagnosis is supported by specific histological characteristics and immunohistochemical staining for CD31, CD34, and FLI-1. Wide surgical resection with tumor-free margins is important for a favorable prognosis.
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spelling pubmed-83585292021-08-13 Retiform hemangioendothelioma: a rare lesion of the vulva Zhang, Mingyue Yin, Xiaojiao Yao, Weikai Liu, Ning Yue, Ying J Int Med Res Case Reports Retiform hemangioendothelioma (RH) is a rare borderline-malignant vascular tumor with specific histological characteristics, usually occurring in the limbs and trunk. We report the case of a 63-year-old woman who presented with a painless, oval nodule that had been growing slowly on her left vulva for 3 years. Magnetic resonance imaging of the pelvic cavity revealed a 4.4- × 2.7- × 1.8-cm cystic lesion in the subcutaneous fat of the left vulva. Resection beyond the macroscopic border was performed. Pathology revealed vascular structures with elongated and narrow arborizing vascular channels that were arranged in a retiform pattern resembling rete testis tissue. Immunohistochemical endothelial staining was positive for CD31, CD34, and Friend leukemia integration-1 (FLI-1). The above features confirmed a diagnosis of RH. There was no local recurrence or metastasis during the 26-month follow-up. RH of the vulva is rare, and its diagnosis is supported by specific histological characteristics and immunohistochemical staining for CD31, CD34, and FLI-1. Wide surgical resection with tumor-free margins is important for a favorable prognosis. SAGE Publications 2021-08-02 /pmc/articles/PMC8358529/ /pubmed/34340581 http://dx.doi.org/10.1177/03000605211027783 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Zhang, Mingyue
Yin, Xiaojiao
Yao, Weikai
Liu, Ning
Yue, Ying
Retiform hemangioendothelioma: a rare lesion of the vulva
title Retiform hemangioendothelioma: a rare lesion of the vulva
title_full Retiform hemangioendothelioma: a rare lesion of the vulva
title_fullStr Retiform hemangioendothelioma: a rare lesion of the vulva
title_full_unstemmed Retiform hemangioendothelioma: a rare lesion of the vulva
title_short Retiform hemangioendothelioma: a rare lesion of the vulva
title_sort retiform hemangioendothelioma: a rare lesion of the vulva
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358529/
https://www.ncbi.nlm.nih.gov/pubmed/34340581
http://dx.doi.org/10.1177/03000605211027783
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