Photosensitizer verteporfin inhibits the growth of YAP- and TAZ-dominant gastric cancer cells by suppressing the anti-apoptotic protein Survivin in a light-independent manner

Yes-associated protein (YAP) positivity indicates a poor prognosis in gastric cancer. Transcriptional co-activator with a PDZ-binding domain (TAZ), a YAP paralog, is highly expressed in gastric signet ring cell carcinoma. Verteporfin (VP), a clinical photosensitizer, was recently shown to inhibit YA...

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Detalles Bibliográficos
Autores principales: Hasegawa, Takashi, Sugihara, Takaaki, Hoshino, Yoshiki, Tarumoto, Ryohei, Matsuki, Yukako, Kanda, Tsutomu, Takata, Tomoaki, Nagahara, Takakazu, Matono, Tomomitsu, Isomoto, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358589/
https://www.ncbi.nlm.nih.gov/pubmed/34457058
http://dx.doi.org/10.3892/ol.2021.12964

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