In Situ Pre-Treatment of Vascularized Composite Allografts With a Targeted Complement Inhibitor Protects Against Brain Death and Ischemia Reperfusion Induced Injuries

INTRODUCTION: Donor brain death (BD) is an unavoidable component of vascularized composite allograft (VCA) transplantation and a key contributor to ischemia-reperfusion injury (IRI). Complement is activated and deposited within solid organ grafts as a consequence of BD and has been shown to exacerba...

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Detalles Bibliográficos
Autores principales: Lei, Biao, Sleiman, M. Mahdi, Cheng, Qi, Tu, Zhenxiao, Zhu, Peng, Goddard, Martin, Martins, Paulo N., Langerude, Logan, Nadig, Satish, Tomlinson, Stephen, Atkinson, Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358649/
https://www.ncbi.nlm.nih.gov/pubmed/34394069
http://dx.doi.org/10.3389/fimmu.2021.630581

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