The p53 Family: A Role in Lipid and Iron Metabolism

The p53 family of tumor suppressors, which includes p53, p63, and p73, has a critical role in many biological processes, such as cell cycle arrest, apoptosis, and differentiation. In addition to tumor suppression, the p53 family proteins also participate in development, multiciliogenesis, and fertil...

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Detalles Bibliográficos
Autores principales: Laubach, Kyra, Zhang, Jin, Chen, Xinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358664/
https://www.ncbi.nlm.nih.gov/pubmed/34395447
http://dx.doi.org/10.3389/fcell.2021.715974
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author Laubach, Kyra
Zhang, Jin
Chen, Xinbin
author_facet Laubach, Kyra
Zhang, Jin
Chen, Xinbin
author_sort Laubach, Kyra
collection PubMed
description The p53 family of tumor suppressors, which includes p53, p63, and p73, has a critical role in many biological processes, such as cell cycle arrest, apoptosis, and differentiation. In addition to tumor suppression, the p53 family proteins also participate in development, multiciliogenesis, and fertility, indicating these proteins have diverse roles. In this review, we strive to cover the relevant studies that demonstrate the roles of p53, p63, and p73 in lipid and iron metabolism.
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spelling pubmed-83586642021-08-13 The p53 Family: A Role in Lipid and Iron Metabolism Laubach, Kyra Zhang, Jin Chen, Xinbin Front Cell Dev Biol Cell and Developmental Biology The p53 family of tumor suppressors, which includes p53, p63, and p73, has a critical role in many biological processes, such as cell cycle arrest, apoptosis, and differentiation. In addition to tumor suppression, the p53 family proteins also participate in development, multiciliogenesis, and fertility, indicating these proteins have diverse roles. In this review, we strive to cover the relevant studies that demonstrate the roles of p53, p63, and p73 in lipid and iron metabolism. Frontiers Media S.A. 2021-07-29 /pmc/articles/PMC8358664/ /pubmed/34395447 http://dx.doi.org/10.3389/fcell.2021.715974 Text en Copyright © 2021 Laubach, Zhang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Laubach, Kyra
Zhang, Jin
Chen, Xinbin
The p53 Family: A Role in Lipid and Iron Metabolism
title The p53 Family: A Role in Lipid and Iron Metabolism
title_full The p53 Family: A Role in Lipid and Iron Metabolism
title_fullStr The p53 Family: A Role in Lipid and Iron Metabolism
title_full_unstemmed The p53 Family: A Role in Lipid and Iron Metabolism
title_short The p53 Family: A Role in Lipid and Iron Metabolism
title_sort p53 family: a role in lipid and iron metabolism
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358664/
https://www.ncbi.nlm.nih.gov/pubmed/34395447
http://dx.doi.org/10.3389/fcell.2021.715974
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