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Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in Trypanosoma brucei

Many eukaryotic cell-surface proteins are post-translationally modified by a glycosylphosphatidylinositol (GPI) moiety that anchors them to the cell membrane. The biosynthesis of GPI anchors is initiated in the endoplasmic reticulum by transfer of GlcNAc from UDP-GlcNAc to phosphatidylinositol. This...

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Detalles Bibliográficos
Autores principales:	Jenni, Aurelio, Knüsel, Sebastian, Nagar, Rupa, Benninger, Mattias, Häner, Robert, Ferguson, Michael A.J., Roditi, Isabel, Menon, Anant K., Bütikofer, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358704/ https://www.ncbi.nlm.nih.gov/pubmed/34284059 http://dx.doi.org/10.1016/j.jbc.2021.100977

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