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Regulation of CTLA‐4 recycling by LRBA and Rab11
CTLA‐4 is an essential regulator of T‐cell immune responses whose intracellular trafficking is a hallmark of its expression. Defects in CTLA‐4 trafficking due to LRBA deficiency cause profound autoimmunity in humans. CTLA‐4 rapidly internalizes via a clathrin‐dependent pathway followed by poorly cha...
Autores principales: | Janman, Daniel, Hinze, Claudia, Kennedy, Alan, Halliday, Neil, Waters, Erin, Williams, Cayman, Rowshanravan, Behzad, Hou, Tie Zheng, Minogue, Shane, Qureshi, Omar S., Sansom, David M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358724/ https://www.ncbi.nlm.nih.gov/pubmed/33960403 http://dx.doi.org/10.1111/imm.13343 |
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