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Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina

PURPOSE: This study aimed to evaluate responses in retinal tissue by swept source OCT angiography (OCT-A) to hyperoxia after hyperbaric oxygen (HBO2) therapy. METHODS: The study was conducted in volunteers who received HBO2 treatment but did not have any eye disease. Patients underwent detailed eye...

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Autores principales: Çevik, Sadık Görkem, Bağlı, Bekir Selim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PUBLISHED BY KNOWLEDGE E 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358766/
https://www.ncbi.nlm.nih.gov/pubmed/34394868
http://dx.doi.org/10.18502/jovr.v16i3.9436
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author Çevik, Sadık Görkem
Bağlı, Bekir Selim
author_facet Çevik, Sadık Görkem
Bağlı, Bekir Selim
author_sort Çevik, Sadık Görkem
collection PubMed
description PURPOSE: This study aimed to evaluate responses in retinal tissue by swept source OCT angiography (OCT-A) to hyperoxia after hyperbaric oxygen (HBO2) therapy. METHODS: The study was conducted in volunteers who received HBO2 treatment but did not have any eye disease. Patients underwent detailed eye examinations including dilated fundus examination, visual acuity, and refraction before being admitted for HBO2 therapy. Measurements were made before and immediately after HBO2 therapy. Enface images of the retinal vasculature were obtained from the superficial and deep retinal plexus (SP/DP). Quantitative analysis of the vessel density (VD) and foveal avascular zone (FAZ) area was performed. RESULTS: In total, 31 patients (15 female) with healthy retina were included in the study. The mean age was 42.8 years. The mean SP vascular density measurements before HBO2 therapy for the right and left eyes were 15.18 [Formula: see text] 1.2 mm [Formula: see text] and 15.01 [Formula: see text] 1.3 mm [Formula: see text] , respectively; the measurements after HBO2 therapy for the right and left eyes were 14.34 [Formula: see text] 1.4 mm [Formula: see text] and 14.48 [Formula: see text] 1.19 mm [Formula: see text] . The mean DP vascular density measurements before HBO2 therapy for the right and left eyes were 16.03 [Formula: see text] 1.69 mm [Formula: see text] and 16.1 [Formula: see text] 1.45 mm [Formula: see text] , respectively; the measurements after HBO2 therapy for the right and left eyes were 15.02 [Formula: see text] 1.65 mm [Formula: see text] and 15.12 [Formula: see text] 2.16 mm [Formula: see text] , respectively. Reduction of mean VD in superficial and deep plexus after HBO2 was statistically significant (P = 0.001 and P = 0.000, respectively). Changes in mean FAZ area before and after HBO2 therapy were not statistically significant (P = 0.719). CONCLUSION: The healthy retina responds to oxygen supersaturation with HBO2 therapy by eventually decreasing vascular density in all layers. These findings may be important for further studies especially related to retina and choroidal oxygenation.
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spelling pubmed-83587662021-08-13 Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina Çevik, Sadık Görkem Bağlı, Bekir Selim J Ophthalmic Vis Res Original Article PURPOSE: This study aimed to evaluate responses in retinal tissue by swept source OCT angiography (OCT-A) to hyperoxia after hyperbaric oxygen (HBO2) therapy. METHODS: The study was conducted in volunteers who received HBO2 treatment but did not have any eye disease. Patients underwent detailed eye examinations including dilated fundus examination, visual acuity, and refraction before being admitted for HBO2 therapy. Measurements were made before and immediately after HBO2 therapy. Enface images of the retinal vasculature were obtained from the superficial and deep retinal plexus (SP/DP). Quantitative analysis of the vessel density (VD) and foveal avascular zone (FAZ) area was performed. RESULTS: In total, 31 patients (15 female) with healthy retina were included in the study. The mean age was 42.8 years. The mean SP vascular density measurements before HBO2 therapy for the right and left eyes were 15.18 [Formula: see text] 1.2 mm [Formula: see text] and 15.01 [Formula: see text] 1.3 mm [Formula: see text] , respectively; the measurements after HBO2 therapy for the right and left eyes were 14.34 [Formula: see text] 1.4 mm [Formula: see text] and 14.48 [Formula: see text] 1.19 mm [Formula: see text] . The mean DP vascular density measurements before HBO2 therapy for the right and left eyes were 16.03 [Formula: see text] 1.69 mm [Formula: see text] and 16.1 [Formula: see text] 1.45 mm [Formula: see text] , respectively; the measurements after HBO2 therapy for the right and left eyes were 15.02 [Formula: see text] 1.65 mm [Formula: see text] and 15.12 [Formula: see text] 2.16 mm [Formula: see text] , respectively. Reduction of mean VD in superficial and deep plexus after HBO2 was statistically significant (P = 0.001 and P = 0.000, respectively). Changes in mean FAZ area before and after HBO2 therapy were not statistically significant (P = 0.719). CONCLUSION: The healthy retina responds to oxygen supersaturation with HBO2 therapy by eventually decreasing vascular density in all layers. These findings may be important for further studies especially related to retina and choroidal oxygenation. PUBLISHED BY KNOWLEDGE E 2021-07-29 /pmc/articles/PMC8358766/ /pubmed/34394868 http://dx.doi.org/10.18502/jovr.v16i3.9436 Text en Copyright © 2021 Çevik et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Çevik, Sadık Görkem
Bağlı, Bekir Selim
Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina
title Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina
title_full Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina
title_fullStr Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina
title_full_unstemmed Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina
title_short Change in the Foveal Avascular Zone and Macular Capillary Network Density after Hyperbaric Oxygen Therapy in Healthy Retina
title_sort change in the foveal avascular zone and macular capillary network density after hyperbaric oxygen therapy in healthy retina
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358766/
https://www.ncbi.nlm.nih.gov/pubmed/34394868
http://dx.doi.org/10.18502/jovr.v16i3.9436
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