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Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages

For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector functions. Thus, recent advances point to lactate as an...

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Autores principales: Manoharan, Indumathi, Prasad, Puttur D., Thangaraju, Muthusamy, Manicassamy, Santhakumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358770/
https://www.ncbi.nlm.nih.gov/pubmed/34394085
http://dx.doi.org/10.3389/fimmu.2021.691134
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author Manoharan, Indumathi
Prasad, Puttur D.
Thangaraju, Muthusamy
Manicassamy, Santhakumar
author_facet Manoharan, Indumathi
Prasad, Puttur D.
Thangaraju, Muthusamy
Manicassamy, Santhakumar
author_sort Manoharan, Indumathi
collection PubMed
description For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector functions. Thus, recent advances point to lactate as an essential and novel signaling molecule that shapes innate and adaptive immune responses in the intestine and systemic sites. Here, we review these recent advances in the context of the pleiotropic effects of lactate in regulating diverse functions of immune cells in the tissue microenvironment and under pathological conditions.
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spelling pubmed-83587702021-08-13 Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages Manoharan, Indumathi Prasad, Puttur D. Thangaraju, Muthusamy Manicassamy, Santhakumar Front Immunol Immunology For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector functions. Thus, recent advances point to lactate as an essential and novel signaling molecule that shapes innate and adaptive immune responses in the intestine and systemic sites. Here, we review these recent advances in the context of the pleiotropic effects of lactate in regulating diverse functions of immune cells in the tissue microenvironment and under pathological conditions. Frontiers Media S.A. 2021-07-29 /pmc/articles/PMC8358770/ /pubmed/34394085 http://dx.doi.org/10.3389/fimmu.2021.691134 Text en Copyright © 2021 Manoharan, Prasad, Thangaraju and Manicassamy https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Manoharan, Indumathi
Prasad, Puttur D.
Thangaraju, Muthusamy
Manicassamy, Santhakumar
Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages
title Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages
title_full Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages
title_fullStr Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages
title_full_unstemmed Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages
title_short Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages
title_sort lactate-dependent regulation of immune responses by dendritic cells and macrophages
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358770/
https://www.ncbi.nlm.nih.gov/pubmed/34394085
http://dx.doi.org/10.3389/fimmu.2021.691134
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