Cargando…
Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages
For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector functions. Thus, recent advances point to lactate as an...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358770/ https://www.ncbi.nlm.nih.gov/pubmed/34394085 http://dx.doi.org/10.3389/fimmu.2021.691134 |
_version_ | 1783737411500507136 |
---|---|
author | Manoharan, Indumathi Prasad, Puttur D. Thangaraju, Muthusamy Manicassamy, Santhakumar |
author_facet | Manoharan, Indumathi Prasad, Puttur D. Thangaraju, Muthusamy Manicassamy, Santhakumar |
author_sort | Manoharan, Indumathi |
collection | PubMed |
description | For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector functions. Thus, recent advances point to lactate as an essential and novel signaling molecule that shapes innate and adaptive immune responses in the intestine and systemic sites. Here, we review these recent advances in the context of the pleiotropic effects of lactate in regulating diverse functions of immune cells in the tissue microenvironment and under pathological conditions. |
format | Online Article Text |
id | pubmed-8358770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83587702021-08-13 Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages Manoharan, Indumathi Prasad, Puttur D. Thangaraju, Muthusamy Manicassamy, Santhakumar Front Immunol Immunology For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector functions. Thus, recent advances point to lactate as an essential and novel signaling molecule that shapes innate and adaptive immune responses in the intestine and systemic sites. Here, we review these recent advances in the context of the pleiotropic effects of lactate in regulating diverse functions of immune cells in the tissue microenvironment and under pathological conditions. Frontiers Media S.A. 2021-07-29 /pmc/articles/PMC8358770/ /pubmed/34394085 http://dx.doi.org/10.3389/fimmu.2021.691134 Text en Copyright © 2021 Manoharan, Prasad, Thangaraju and Manicassamy https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Manoharan, Indumathi Prasad, Puttur D. Thangaraju, Muthusamy Manicassamy, Santhakumar Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages |
title | Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages |
title_full | Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages |
title_fullStr | Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages |
title_full_unstemmed | Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages |
title_short | Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages |
title_sort | lactate-dependent regulation of immune responses by dendritic cells and macrophages |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358770/ https://www.ncbi.nlm.nih.gov/pubmed/34394085 http://dx.doi.org/10.3389/fimmu.2021.691134 |
work_keys_str_mv | AT manoharanindumathi lactatedependentregulationofimmuneresponsesbydendriticcellsandmacrophages AT prasadputturd lactatedependentregulationofimmuneresponsesbydendriticcellsandmacrophages AT thangarajumuthusamy lactatedependentregulationofimmuneresponsesbydendriticcellsandmacrophages AT manicassamysanthakumar lactatedependentregulationofimmuneresponsesbydendriticcellsandmacrophages |