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Sensitive Measurement of Drug-Target Engagement by a Cellular Thermal Shift Assay with Multiplex Proximity Extension Readout

[Image: see text] The ability to monitor target engagement in cellular contexts is a key for successful drug discovery and also valuable in clinical routine. A cellular thermal shift assay (CETSA) provides realistic information about drug binding in cells and tissues, revealing drug-target engagemen...

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Detalles Bibliográficos
Autores principales:	Al-Amin, Rasel A., Gallant, Caroline J., Muthelo, Phathutshedzo M., Landegren, Ulf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358919/ https://www.ncbi.nlm.nih.gov/pubmed/34319715 http://dx.doi.org/10.1021/acs.analchem.1c02225

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