Cargando…
Influence of Tumor Burden on Serum Prostate-Specific Antigen in Prostate Cancer Patients Undergoing Radical Prostatectomy
OBJECTIVE: We aimed to assess the correlation between serum prostate-specific antigen (PSA) and tumor burden in prostate cancer (PCa) patients undergoing radical prostatectomy (RP), because estimation of tumor burden is of high value, e.g., in men undergoing RP or with biochemical recurrence after R...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358926/ https://www.ncbi.nlm.nih.gov/pubmed/34395240 http://dx.doi.org/10.3389/fonc.2021.656444 |
_version_ | 1783737440097271808 |
---|---|
author | Mandel, Philipp Hoeh, Benedikt Preisser, Felix Wenzel, Mike Humke, Clara Welte, Maria-Noemi Jerrentrup, Inga Köllermann, Jens Wild, Peter Tilki, Derya Haese, Alexander Becker, Andreas Roos, Frederik C. Chun, Felix K. H. Kluth, Luis A. |
author_facet | Mandel, Philipp Hoeh, Benedikt Preisser, Felix Wenzel, Mike Humke, Clara Welte, Maria-Noemi Jerrentrup, Inga Köllermann, Jens Wild, Peter Tilki, Derya Haese, Alexander Becker, Andreas Roos, Frederik C. Chun, Felix K. H. Kluth, Luis A. |
author_sort | Mandel, Philipp |
collection | PubMed |
description | OBJECTIVE: We aimed to assess the correlation between serum prostate-specific antigen (PSA) and tumor burden in prostate cancer (PCa) patients undergoing radical prostatectomy (RP), because estimation of tumor burden is of high value, e.g., in men undergoing RP or with biochemical recurrence after RP. PATIENTS AND METHODS: From January 2019 to June 2020, 179 consecutive PCa patients after RP with information on tumor and prostate weight were retrospectively identified from our prospective institutional RP database. Patients with preoperative systemic therapy (n=19), metastases (cM1, n=5), and locally progressed PCa (pT4 or pN1, n=50) were excluded from analyses. Histopathological features, including total weight of the prostate and specific tumor weight, were recorded by specialized uro-pathologists. Linear regression models were performed to evaluate the effect of PSA on tumor burden, measured by tumor weight after adjustment for patient and tumor characteristics. RESULTS: Overall, median preoperative PSA was 7.0 ng/ml (interquartile range [IQR]: 5.41–10) and median age at surgery was 66 years (IQR: 61-71). Median prostate weight was 34 g (IQR: 26–46) and median tumor weight was 3.7 g (IQR: 1.8–7.1), respectively. In multivariable linear regression analysis after adjustment for patients and tumor characteristics, a significant, positive correlation could be detected between preoperative PSA and tumor weight (coefficient [coef.]: 0.37, CI: 0.15–0.6, p=0.001), indicating a robust increase in PSA of almost 0.4 ng/ml per 1g tumor weight. CONCLUSION: Preoperative PSA was significantly correlated with tumor weight in PCa patients undergoing RP, with an increase in PSA of almost 0.4 ng/ml per 1 g tumor weight. This might help to estimate both tumor burden before undergoing RP and in case of biochemical recurrence. |
format | Online Article Text |
id | pubmed-8358926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83589262021-08-13 Influence of Tumor Burden on Serum Prostate-Specific Antigen in Prostate Cancer Patients Undergoing Radical Prostatectomy Mandel, Philipp Hoeh, Benedikt Preisser, Felix Wenzel, Mike Humke, Clara Welte, Maria-Noemi Jerrentrup, Inga Köllermann, Jens Wild, Peter Tilki, Derya Haese, Alexander Becker, Andreas Roos, Frederik C. Chun, Felix K. H. Kluth, Luis A. Front Oncol Oncology OBJECTIVE: We aimed to assess the correlation between serum prostate-specific antigen (PSA) and tumor burden in prostate cancer (PCa) patients undergoing radical prostatectomy (RP), because estimation of tumor burden is of high value, e.g., in men undergoing RP or with biochemical recurrence after RP. PATIENTS AND METHODS: From January 2019 to June 2020, 179 consecutive PCa patients after RP with information on tumor and prostate weight were retrospectively identified from our prospective institutional RP database. Patients with preoperative systemic therapy (n=19), metastases (cM1, n=5), and locally progressed PCa (pT4 or pN1, n=50) were excluded from analyses. Histopathological features, including total weight of the prostate and specific tumor weight, were recorded by specialized uro-pathologists. Linear regression models were performed to evaluate the effect of PSA on tumor burden, measured by tumor weight after adjustment for patient and tumor characteristics. RESULTS: Overall, median preoperative PSA was 7.0 ng/ml (interquartile range [IQR]: 5.41–10) and median age at surgery was 66 years (IQR: 61-71). Median prostate weight was 34 g (IQR: 26–46) and median tumor weight was 3.7 g (IQR: 1.8–7.1), respectively. In multivariable linear regression analysis after adjustment for patients and tumor characteristics, a significant, positive correlation could be detected between preoperative PSA and tumor weight (coefficient [coef.]: 0.37, CI: 0.15–0.6, p=0.001), indicating a robust increase in PSA of almost 0.4 ng/ml per 1g tumor weight. CONCLUSION: Preoperative PSA was significantly correlated with tumor weight in PCa patients undergoing RP, with an increase in PSA of almost 0.4 ng/ml per 1 g tumor weight. This might help to estimate both tumor burden before undergoing RP and in case of biochemical recurrence. Frontiers Media S.A. 2021-07-29 /pmc/articles/PMC8358926/ /pubmed/34395240 http://dx.doi.org/10.3389/fonc.2021.656444 Text en Copyright © 2021 Mandel, Hoeh, Preisser, Wenzel, Humke, Welte, Jerrentrup, Köllermann, Wild, Tilki, Haese, Becker, Roos, Chun and Kluth https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Mandel, Philipp Hoeh, Benedikt Preisser, Felix Wenzel, Mike Humke, Clara Welte, Maria-Noemi Jerrentrup, Inga Köllermann, Jens Wild, Peter Tilki, Derya Haese, Alexander Becker, Andreas Roos, Frederik C. Chun, Felix K. H. Kluth, Luis A. Influence of Tumor Burden on Serum Prostate-Specific Antigen in Prostate Cancer Patients Undergoing Radical Prostatectomy |
title | Influence of Tumor Burden on Serum Prostate-Specific Antigen in Prostate Cancer Patients Undergoing Radical Prostatectomy |
title_full | Influence of Tumor Burden on Serum Prostate-Specific Antigen in Prostate Cancer Patients Undergoing Radical Prostatectomy |
title_fullStr | Influence of Tumor Burden on Serum Prostate-Specific Antigen in Prostate Cancer Patients Undergoing Radical Prostatectomy |
title_full_unstemmed | Influence of Tumor Burden on Serum Prostate-Specific Antigen in Prostate Cancer Patients Undergoing Radical Prostatectomy |
title_short | Influence of Tumor Burden on Serum Prostate-Specific Antigen in Prostate Cancer Patients Undergoing Radical Prostatectomy |
title_sort | influence of tumor burden on serum prostate-specific antigen in prostate cancer patients undergoing radical prostatectomy |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358926/ https://www.ncbi.nlm.nih.gov/pubmed/34395240 http://dx.doi.org/10.3389/fonc.2021.656444 |
work_keys_str_mv | AT mandelphilipp influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT hoehbenedikt influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT preisserfelix influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT wenzelmike influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT humkeclara influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT weltemarianoemi influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT jerrentrupinga influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT kollermannjens influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT wildpeter influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT tilkiderya influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT haesealexander influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT beckerandreas influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT roosfrederikc influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT chunfelixkh influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy AT kluthluisa influenceoftumorburdenonserumprostatespecificantigeninprostatecancerpatientsundergoingradicalprostatectomy |