CBr(4) Mediated [4 + 1] Dehydrocyclization for the Synthesis of Functionalized Imidazo[1,5-a]heterocycles from Pyridin-2-ylmethanamines and Aldehydes

[Image: see text] A CBr(4) mediated [4 + 1] dehydrocyclization was developed for the synthesis of imidazo[1,5-a]heterocycles from pyridin-2-ylmethanamines and aldehydes. This method was highly practical with the advantages of wide substrate scope, functional group tolerance, and mild reaction condit...

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Autores principales: Wang, Qiang, Zha, Meng, Zhou, Feilong, Chen, Xixi, Wang, Baiyu, Liu, Guodong, Qian, Lisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358950/
https://www.ncbi.nlm.nih.gov/pubmed/34395978
http://dx.doi.org/10.1021/acsomega.1c02181
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author Wang, Qiang
Zha, Meng
Zhou, Feilong
Chen, Xixi
Wang, Baiyu
Liu, Guodong
Qian, Lisheng
author_facet Wang, Qiang
Zha, Meng
Zhou, Feilong
Chen, Xixi
Wang, Baiyu
Liu, Guodong
Qian, Lisheng
author_sort Wang, Qiang
collection PubMed
description [Image: see text] A CBr(4) mediated [4 + 1] dehydrocyclization was developed for the synthesis of imidazo[1,5-a]heterocycles from pyridin-2-ylmethanamines and aldehydes. This method was highly practical with the advantages of wide substrate scope, functional group tolerance, and mild reaction conditions.
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spelling pubmed-83589502021-08-13 CBr(4) Mediated [4 + 1] Dehydrocyclization for the Synthesis of Functionalized Imidazo[1,5-a]heterocycles from Pyridin-2-ylmethanamines and Aldehydes Wang, Qiang Zha, Meng Zhou, Feilong Chen, Xixi Wang, Baiyu Liu, Guodong Qian, Lisheng ACS Omega [Image: see text] A CBr(4) mediated [4 + 1] dehydrocyclization was developed for the synthesis of imidazo[1,5-a]heterocycles from pyridin-2-ylmethanamines and aldehydes. This method was highly practical with the advantages of wide substrate scope, functional group tolerance, and mild reaction conditions. American Chemical Society 2021-08-02 /pmc/articles/PMC8358950/ /pubmed/34395978 http://dx.doi.org/10.1021/acsomega.1c02181 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Wang, Qiang
Zha, Meng
Zhou, Feilong
Chen, Xixi
Wang, Baiyu
Liu, Guodong
Qian, Lisheng
CBr(4) Mediated [4 + 1] Dehydrocyclization for the Synthesis of Functionalized Imidazo[1,5-a]heterocycles from Pyridin-2-ylmethanamines and Aldehydes
title CBr(4) Mediated [4 + 1] Dehydrocyclization for the Synthesis of Functionalized Imidazo[1,5-a]heterocycles from Pyridin-2-ylmethanamines and Aldehydes
title_full CBr(4) Mediated [4 + 1] Dehydrocyclization for the Synthesis of Functionalized Imidazo[1,5-a]heterocycles from Pyridin-2-ylmethanamines and Aldehydes
title_fullStr CBr(4) Mediated [4 + 1] Dehydrocyclization for the Synthesis of Functionalized Imidazo[1,5-a]heterocycles from Pyridin-2-ylmethanamines and Aldehydes
title_full_unstemmed CBr(4) Mediated [4 + 1] Dehydrocyclization for the Synthesis of Functionalized Imidazo[1,5-a]heterocycles from Pyridin-2-ylmethanamines and Aldehydes
title_short CBr(4) Mediated [4 + 1] Dehydrocyclization for the Synthesis of Functionalized Imidazo[1,5-a]heterocycles from Pyridin-2-ylmethanamines and Aldehydes
title_sort cbr(4) mediated [4 + 1] dehydrocyclization for the synthesis of functionalized imidazo[1,5-a]heterocycles from pyridin-2-ylmethanamines and aldehydes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358950/
https://www.ncbi.nlm.nih.gov/pubmed/34395978
http://dx.doi.org/10.1021/acsomega.1c02181
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