Polyamine metabolism is a central determinant of helper T cell lineage fidelity

Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but the biological implications of this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing the ability of CD4(+) helper T cells (T(H)) to polarize into diff...

Descripción completa

Detalles Bibliográficos
Autores principales: Puleston, Daniel J., Baixauli, Francesc, Sanin, David E., Edwards-Hicks, Joy, Villa, Matteo, Kabat, Agnieszka M., Kamiński, Marcin M., Stanckzak, Michal, Weiss, Hauke J., Grzes, Katarzyna M., Piletic, Klara, Field, Cameron S., Corrado, Mauro, Haessler, Fabian, Wang, Chao, Musa, Yaarub, Schimmelpfennig, Lena, Flachsmann, Lea, Mittler, Gerhard, Yosef, Nir, Kuchroo, Vijay K., Buescher, Joerg M., Balabanov, Stefan, Pearce, Edward J., Green, Douglas R., Pearce, Erika L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358979/
https://www.ncbi.nlm.nih.gov/pubmed/34216540
http://dx.doi.org/10.1016/j.cell.2021.06.007

Ejemplares similares

Ejemplares similares