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Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them?

Patients in sub‐Saharan Africa generally have poor anticoagulation control. We review the potential reasons for this poor control, as well as the potential solutions. Challenges include the affordability and centralisation of anticoagulation care, problems with access to medicines and international...

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Autores principales: Mouton, Johannes P., Blockman, Marc, Sekaggya‐Wiltshire, Christine, Semakula, Jerome, Waitt, Catriona, Pirmohamed, Munir, Cohen, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359270/
https://www.ncbi.nlm.nih.gov/pubmed/33586223
http://dx.doi.org/10.1111/bcp.14768
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author Mouton, Johannes P.
Blockman, Marc
Sekaggya‐Wiltshire, Christine
Semakula, Jerome
Waitt, Catriona
Pirmohamed, Munir
Cohen, Karen
author_facet Mouton, Johannes P.
Blockman, Marc
Sekaggya‐Wiltshire, Christine
Semakula, Jerome
Waitt, Catriona
Pirmohamed, Munir
Cohen, Karen
author_sort Mouton, Johannes P.
collection PubMed
description Patients in sub‐Saharan Africa generally have poor anticoagulation control. We review the potential reasons for this poor control, as well as the potential solutions. Challenges include the affordability and centralisation of anticoagulation care, problems with access to medicines and international normalised ratio monitoring, the lack of locally validated standardized dosing protocols, and low levels of anticoagulation knowledge among healthcare workers and patients. Increasing numbers of patients will need anticoagulation in the future because of the increasing burden of noncommunicable disease in the region. We propose that locally developed “warfarin care bundles” which address multiple anticoagulation challenges in combination may be the most appropriate solution in this setting currently.
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spelling pubmed-83592702021-08-17 Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them? Mouton, Johannes P. Blockman, Marc Sekaggya‐Wiltshire, Christine Semakula, Jerome Waitt, Catriona Pirmohamed, Munir Cohen, Karen Br J Clin Pharmacol Review Articles Patients in sub‐Saharan Africa generally have poor anticoagulation control. We review the potential reasons for this poor control, as well as the potential solutions. Challenges include the affordability and centralisation of anticoagulation care, problems with access to medicines and international normalised ratio monitoring, the lack of locally validated standardized dosing protocols, and low levels of anticoagulation knowledge among healthcare workers and patients. Increasing numbers of patients will need anticoagulation in the future because of the increasing burden of noncommunicable disease in the region. We propose that locally developed “warfarin care bundles” which address multiple anticoagulation challenges in combination may be the most appropriate solution in this setting currently. John Wiley and Sons Inc. 2021-03-10 2021-08 /pmc/articles/PMC8359270/ /pubmed/33586223 http://dx.doi.org/10.1111/bcp.14768 Text en © 2021 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Mouton, Johannes P.
Blockman, Marc
Sekaggya‐Wiltshire, Christine
Semakula, Jerome
Waitt, Catriona
Pirmohamed, Munir
Cohen, Karen
Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them?
title Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them?
title_full Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them?
title_fullStr Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them?
title_full_unstemmed Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them?
title_short Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them?
title_sort improving anticoagulation in sub‐saharan africa: what are the challenges and how can we overcome them?
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359270/
https://www.ncbi.nlm.nih.gov/pubmed/33586223
http://dx.doi.org/10.1111/bcp.14768
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