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Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them?
Patients in sub‐Saharan Africa generally have poor anticoagulation control. We review the potential reasons for this poor control, as well as the potential solutions. Challenges include the affordability and centralisation of anticoagulation care, problems with access to medicines and international...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359270/ https://www.ncbi.nlm.nih.gov/pubmed/33586223 http://dx.doi.org/10.1111/bcp.14768 |
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author | Mouton, Johannes P. Blockman, Marc Sekaggya‐Wiltshire, Christine Semakula, Jerome Waitt, Catriona Pirmohamed, Munir Cohen, Karen |
author_facet | Mouton, Johannes P. Blockman, Marc Sekaggya‐Wiltshire, Christine Semakula, Jerome Waitt, Catriona Pirmohamed, Munir Cohen, Karen |
author_sort | Mouton, Johannes P. |
collection | PubMed |
description | Patients in sub‐Saharan Africa generally have poor anticoagulation control. We review the potential reasons for this poor control, as well as the potential solutions. Challenges include the affordability and centralisation of anticoagulation care, problems with access to medicines and international normalised ratio monitoring, the lack of locally validated standardized dosing protocols, and low levels of anticoagulation knowledge among healthcare workers and patients. Increasing numbers of patients will need anticoagulation in the future because of the increasing burden of noncommunicable disease in the region. We propose that locally developed “warfarin care bundles” which address multiple anticoagulation challenges in combination may be the most appropriate solution in this setting currently. |
format | Online Article Text |
id | pubmed-8359270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83592702021-08-17 Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them? Mouton, Johannes P. Blockman, Marc Sekaggya‐Wiltshire, Christine Semakula, Jerome Waitt, Catriona Pirmohamed, Munir Cohen, Karen Br J Clin Pharmacol Review Articles Patients in sub‐Saharan Africa generally have poor anticoagulation control. We review the potential reasons for this poor control, as well as the potential solutions. Challenges include the affordability and centralisation of anticoagulation care, problems with access to medicines and international normalised ratio monitoring, the lack of locally validated standardized dosing protocols, and low levels of anticoagulation knowledge among healthcare workers and patients. Increasing numbers of patients will need anticoagulation in the future because of the increasing burden of noncommunicable disease in the region. We propose that locally developed “warfarin care bundles” which address multiple anticoagulation challenges in combination may be the most appropriate solution in this setting currently. John Wiley and Sons Inc. 2021-03-10 2021-08 /pmc/articles/PMC8359270/ /pubmed/33586223 http://dx.doi.org/10.1111/bcp.14768 Text en © 2021 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Mouton, Johannes P. Blockman, Marc Sekaggya‐Wiltshire, Christine Semakula, Jerome Waitt, Catriona Pirmohamed, Munir Cohen, Karen Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them? |
title | Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them? |
title_full | Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them? |
title_fullStr | Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them? |
title_full_unstemmed | Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them? |
title_short | Improving anticoagulation in sub‐Saharan Africa: What are the challenges and how can we overcome them? |
title_sort | improving anticoagulation in sub‐saharan africa: what are the challenges and how can we overcome them? |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359270/ https://www.ncbi.nlm.nih.gov/pubmed/33586223 http://dx.doi.org/10.1111/bcp.14768 |
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