Cargando…

Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia

BACKGROUND: Over 200 schizophrenia risk loci have been identified by genome-wide association studies (GWASs). However, the majority of risk loci were identified in populations of European ancestry (EUR), potentially missing important biological insights. It is important to perform 5 GWASs in non-Eur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jiewei, Li, Shiwu, Li, Xiaoyan, Li, Wenqiang, Yang, Yongfeng, Guo, Suqin, Lv, Luxian, Xiao, Xiao, Yao, Yong-Gang, Guan, Fanglin, Li, Ming, Luo, Xiong-Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359304/ https://www.ncbi.nlm.nih.gov/pubmed/34380480 http://dx.doi.org/10.1186/s12916-021-02039-9

Ejemplares similares

Genome wide association study identifies four loci for early onset schizophrenia
por: Guo, Suqin, et al.
Publicado: (2021)

Genome-Wide Meta-Analysis Identifies Two Novel Risk Loci for Epilepsy
por: Song, Meng, et al.
Publicado: (2021)

Identification of a Risk Locus at 7p22.3 for Schizophrenia and Bipolar Disorder in East Asian Populations
por: Li, Wenqiang, et al.
Publicado: (2021)

Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression
por: Li, Yifan, et al.
Publicado: (2022)

Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety
por: Su, Xi, et al.
Publicado: (2021)

Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations
por: Yang, Yongfeng, et al.
Publicado: (2018)

Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
por: Huo, Yongxia, et al.
Publicado: (2019)

The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density
por: Li, Shiwu, et al.
Publicado: (2022)

Weak Association Between the Glutamate Decarboxylase 1 Gene (GAD1) and Schizophrenia in Han Chinese Population
por: Zhang, Luwen, et al.
Publicado: (2021)

Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression
por: Li, Shiwu, et al.
Publicado: (2021)

ATAD3B and SKIL polymorphisms associated with antipsychotic-induced QTc interval change in patients with schizophrenia: a genome-wide association study
por: Lu, Zhe, et al.
Publicado: (2022)

Association of estrogen receptor alpha gene polymorphism with age at onset, general psychopathology symptoms, and therapeutic effect of schizophrenia
por: Wang, Shuai, et al.
Publicado: (2013)

Association between Ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients
por: Yang, Yongfeng, et al.
Publicado: (2012)

Association Study of N-Methyl-D-Aspartate Receptor Subunit 2B (GRIN2B) Polymorphisms and Schizophrenia Symptoms in the Han Chinese Population
por: Yang, Yongfeng, et al.
Publicado: (2015)

Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population
por: Yang, Yongfeng, et al.
Publicado: (2018)

Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder
por: Yang, Yongfeng, et al.
Publicado: (2019)

Associations between expression of indoleamine 2, 3-dioxygenase enzyme and inflammatory cytokines in patients with first-episode drug-naive Schizophrenia
por: Zhang, Yan, et al.
Publicado: (2021)

Transcriptome-wide association study identifies new susceptibility genes and pathways for depression
por: Li, Xiaoyan, et al.
Publicado: (2021)

Association of ARHGAP18 polymorphisms with schizophrenia in the Chinese-Han population
por: Guo, Weiyun, et al.
Publicado: (2017)

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
por: Conti, David V., et al.
Publicado: (2021)

Abnormal functional connectivity of the striatum in first‐episode drug‐naive early‐onset Schizophrenia
por: Zhang, Yan, et al.
Publicado: (2022)

Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study
por: Yang, Yongfeng, et al.
Publicado: (2022)

Cortical anatomical variations, gene expression profiles, and clinical phenotypes in patients with schizophrenia
por: Han, Yong, et al.
Publicado: (2023)

Trans-Ancestry Mutation Landscape of Hepatoblastoma Genomes in Children
por: Liu, Jie, et al.
Publicado: (2021)

The nuclear factor-κB inhibitor pyrrolidine dithiocarbamate reduces polyinosinic-polycytidilic acid-induced immune response in pregnant rats and the behavioral defects of their adult offspring
por: Song, Xueqin, et al.
Publicado: (2011)

Association of SYNE1 locus with bipolar disorder in Chinese population
por: Li, Wenqiang, et al.
Publicado: (2019)

Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants
por: Chen, Rui, et al.
Publicado: (2022)

Genetic regulatory and biological implications of the 10q24.32 schizophrenia risk locus
por: Wang, Junyang, et al.
Publicado: (2022)

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci
por: Liu, Ching-Ti, et al.
Publicado: (2013)

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
por: Wyss, Annah B., et al.
Publicado: (2018)

A Genome-Wide Association Study of Suicide Attempts in the Million Veterans Program Identifies Evidence of Pan-Ancestry and Ancestry-Specific Risk Loci
por: Kimbrel, Nathan A., et al.
Publicado: (2022)

Solute Carrier Family 1 (SLC1A1) Contributes to Susceptibility and Psychopathology Symptoms of Schizophrenia in the Han Chinese Population
por: Li, Wenqiang, et al.
Publicado: (2020)

16 Cross-ancestry analysis of preeclampsia identifies novel maternal susceptibility loci
por: Greene, Catherine A., et al.
Publicado: (2023)

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium
por: Ng, Maggie C. Y., et al.
Publicado: (2017)

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
por: Gharahkhani, Puya, et al.
Publicado: (2021)

Decreased Functional Connectivity of Insular Cortex in Drug Naïve First Episode Schizophrenia: In Relation to Symptom Severity
por: Pang, Lijuan, et al.
Publicado: (2017)

Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry
por: Newton-Cheh, Christopher, et al.
Publicado: (2009)

Genome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program
por: Ashley-Koch, Allison E., et al.
Publicado: (2023)

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Publicado: (2014)

Abnormal patterns of regional homogeneity and functional connectivity across the adolescent first-episode, adult first-episode and adult chronic schizophrenia
por: Yang, Yongfeng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ro4ec7gnfgjcv84b1ue933j46k