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A human induced pluripotent stem cell‐based modular platform to challenge sensorineural hearing loss

The sense of hearing depends on a specialized sensory organ in the inner ear, called the cochlea, which contains the auditory hair cells (HCs). Noise trauma, infections, genetic factors, side effects of ototoxic drugs (ie, some antibiotics and chemotherapeutics), or simply aging lead to the loss of...

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Detalles Bibliográficos
Autores principales: Zine, Azel, Messat, Yassine, Fritzsch, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359331/
https://www.ncbi.nlm.nih.gov/pubmed/33522002
http://dx.doi.org/10.1002/stem.3346
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author Zine, Azel
Messat, Yassine
Fritzsch, Bernd
author_facet Zine, Azel
Messat, Yassine
Fritzsch, Bernd
author_sort Zine, Azel
collection PubMed
description The sense of hearing depends on a specialized sensory organ in the inner ear, called the cochlea, which contains the auditory hair cells (HCs). Noise trauma, infections, genetic factors, side effects of ototoxic drugs (ie, some antibiotics and chemotherapeutics), or simply aging lead to the loss of HCs and their associated primary neurons. This results in irreversible sensorineural hearing loss (SNHL) as in mammals, including humans; the inner ear lacks the capacity to regenerate HCs and spiral ganglion neurons. SNHL is a major global health problem affecting millions of people worldwide and provides a growing concern in the aging population. To date, treatment options are limited to hearing aids and cochlear implants. A major bottleneck for development of new therapies for SNHL is associated to the lack of human otic cell bioassays. Human induced pluripotent stem cells (hiPSCs) can be induced in two‐dimensional and three‐dimensional otic cells in vitro models that can generate inner ear progenitors and sensory HCs and could be a promising preclinical platform from which to work toward restoring SNHL. We review the potential applications of hiPSCs in the various biological approaches, including disease modeling, bioengineering, drug testing, and autologous stem cell based‐cell therapy, that offer opportunities to understand the pathogenic mechanisms of SNHL and identify novel therapeutic strategies.
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spelling pubmed-83593312021-08-17 A human induced pluripotent stem cell‐based modular platform to challenge sensorineural hearing loss Zine, Azel Messat, Yassine Fritzsch, Bernd Stem Cells Concise Reviews The sense of hearing depends on a specialized sensory organ in the inner ear, called the cochlea, which contains the auditory hair cells (HCs). Noise trauma, infections, genetic factors, side effects of ototoxic drugs (ie, some antibiotics and chemotherapeutics), or simply aging lead to the loss of HCs and their associated primary neurons. This results in irreversible sensorineural hearing loss (SNHL) as in mammals, including humans; the inner ear lacks the capacity to regenerate HCs and spiral ganglion neurons. SNHL is a major global health problem affecting millions of people worldwide and provides a growing concern in the aging population. To date, treatment options are limited to hearing aids and cochlear implants. A major bottleneck for development of new therapies for SNHL is associated to the lack of human otic cell bioassays. Human induced pluripotent stem cells (hiPSCs) can be induced in two‐dimensional and three‐dimensional otic cells in vitro models that can generate inner ear progenitors and sensory HCs and could be a promising preclinical platform from which to work toward restoring SNHL. We review the potential applications of hiPSCs in the various biological approaches, including disease modeling, bioengineering, drug testing, and autologous stem cell based‐cell therapy, that offer opportunities to understand the pathogenic mechanisms of SNHL and identify novel therapeutic strategies. John Wiley & Sons, Inc. 2021-02-08 2021-06 /pmc/articles/PMC8359331/ /pubmed/33522002 http://dx.doi.org/10.1002/stem.3346 Text en © 2021 The Authors. stem cells published by Wiley Periodicals LLC on behalf of AlphaMed Press 2021 https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Concise Reviews
Zine, Azel
Messat, Yassine
Fritzsch, Bernd
A human induced pluripotent stem cell‐based modular platform to challenge sensorineural hearing loss
title A human induced pluripotent stem cell‐based modular platform to challenge sensorineural hearing loss
title_full A human induced pluripotent stem cell‐based modular platform to challenge sensorineural hearing loss
title_fullStr A human induced pluripotent stem cell‐based modular platform to challenge sensorineural hearing loss
title_full_unstemmed A human induced pluripotent stem cell‐based modular platform to challenge sensorineural hearing loss
title_short A human induced pluripotent stem cell‐based modular platform to challenge sensorineural hearing loss
title_sort human induced pluripotent stem cell‐based modular platform to challenge sensorineural hearing loss
topic Concise Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359331/
https://www.ncbi.nlm.nih.gov/pubmed/33522002
http://dx.doi.org/10.1002/stem.3346
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