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The multifaceted role of cell cycle regulators in the coordination of growth and metabolism
Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi‐directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the family of cyclin‐dependent kinases (CDKs), their regula...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359344/ https://www.ncbi.nlm.nih.gov/pubmed/33030287 http://dx.doi.org/10.1111/febs.15586 |
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author | Huber, Katharina Mestres‐Arenas, Alberto Fajas, Lluis Leal‐Esteban, Lucia C. |
author_facet | Huber, Katharina Mestres‐Arenas, Alberto Fajas, Lluis Leal‐Esteban, Lucia C. |
author_sort | Huber, Katharina |
collection | PubMed |
description | Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi‐directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the family of cyclin‐dependent kinases (CDKs), their regulatory subunits known as cyclins, CDK inhibitors, the retinoblastoma family members, and the E2F transcription factors). Deciphering the mechanisms accountable for this coordination is crucial for understanding various patho‐physiological processes. While it is well established that metabolism and growth affect cell division, this review will focus on recent observations that demonstrate how cell cycle regulators coordinate metabolism, cell cycle progression, and growth. We will discuss how the cell cycle regulators directly regulate metabolic enzymes and pathways and summarize their involvement in the endolysosomal pathway and in the functions and dynamics of mitochondria. |
format | Online Article Text |
id | pubmed-8359344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83593442021-08-17 The multifaceted role of cell cycle regulators in the coordination of growth and metabolism Huber, Katharina Mestres‐Arenas, Alberto Fajas, Lluis Leal‐Esteban, Lucia C. FEBS J State‐of‐the‐Art Reviews Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi‐directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the family of cyclin‐dependent kinases (CDKs), their regulatory subunits known as cyclins, CDK inhibitors, the retinoblastoma family members, and the E2F transcription factors). Deciphering the mechanisms accountable for this coordination is crucial for understanding various patho‐physiological processes. While it is well established that metabolism and growth affect cell division, this review will focus on recent observations that demonstrate how cell cycle regulators coordinate metabolism, cell cycle progression, and growth. We will discuss how the cell cycle regulators directly regulate metabolic enzymes and pathways and summarize their involvement in the endolysosomal pathway and in the functions and dynamics of mitochondria. John Wiley and Sons Inc. 2020-10-25 2021-06 /pmc/articles/PMC8359344/ /pubmed/33030287 http://dx.doi.org/10.1111/febs.15586 Text en © 2020 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | State‐of‐the‐Art Reviews Huber, Katharina Mestres‐Arenas, Alberto Fajas, Lluis Leal‐Esteban, Lucia C. The multifaceted role of cell cycle regulators in the coordination of growth and metabolism |
title | The multifaceted role of cell cycle regulators in the coordination of growth and metabolism |
title_full | The multifaceted role of cell cycle regulators in the coordination of growth and metabolism |
title_fullStr | The multifaceted role of cell cycle regulators in the coordination of growth and metabolism |
title_full_unstemmed | The multifaceted role of cell cycle regulators in the coordination of growth and metabolism |
title_short | The multifaceted role of cell cycle regulators in the coordination of growth and metabolism |
title_sort | multifaceted role of cell cycle regulators in the coordination of growth and metabolism |
topic | State‐of‐the‐Art Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359344/ https://www.ncbi.nlm.nih.gov/pubmed/33030287 http://dx.doi.org/10.1111/febs.15586 |
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