Cargando…

The ratio of ursodeoxycholyltaurine to 7‐oxolithocholyltaurine serves as a biomarker of decreased 11β‐hydroxysteroid dehydrogenase 1 activity in mouse

BACKGROUND AND PURPOSE: 11β‐Hydroxysteroid dehydrogenase 1 (11β‐HSD1) regulates tissue‐specific glucocorticoid metabolism and its impaired expression and activity are associated with major diseases. Pharmacological inhibition of 11β‐HSD1 is considered a promising therapeutic strategy. This study inv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weingartner, Michael, Stücheli, Simon, Kratschmar, Denise V., Birk, Julia, Klusonova, Petra, Chapman, Karen E., Lavery, Gareth G., Odermatt, Alex
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Oxysterols, Lifelong Health and Therapeutics–Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359391/ https://www.ncbi.nlm.nih.gov/pubmed/33450045 http://dx.doi.org/10.1111/bph.15367

Ejemplares similares

Sex difference in flux of 27‐hydroxycholesterol into the brain
por: Parrado‐Fernandez, Cristina, et al.
Publicado: (2021)

Early or deferred initiation of efavirenz during rifampicin‐based TB therapy has no significant effect on CYP3A induction in TB‐HIV infected patients
por: Aklillu, Eleni, et al.
Publicado: (2020)

Posaconazole-Induced Hypertension Due to Inhibition of 11β-Hydroxylase and 11β-Hydroxysteroid Dehydrogenase 2
por: Thompson, George R, et al.
Publicado: (2019)

11β-Hydroxysteroid dehydrogenases control access of 7β,27-dihydroxycholesterol to retinoid-related orphan receptor γ
por: Beck, Katharina R., et al.
Publicado: (2019)

Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples
por: Gómez, Cristina, et al.
Publicado: (2020)

11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice()
por: Penno, Carlos A., et al.
Publicado: (2014)

Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary–gonadal axis of primates
por: Bird, A Daniel, et al.
Publicado: (2017)

Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV
por: Boudon, Stéphanie M., et al.
Publicado: (2017)

Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 and 7α-Hydroxylase CYP7B1 during Social Stress
por: Vodička, Martin, et al.
Publicado: (2014)

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases
por: Kaserer, Teresa, et al.
Publicado: (2015)

Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis
por: Lee, Noo Ri, et al.
Publicado: (2020)

Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases
por: Engeli, Roger T., et al.
Publicado: (2017)

Organotins Disrupt the 11β-Hydroxysteroid Dehydrogenase Type 2–Dependent Local Inactivation of Glucocorticoids
por: Atanasov, Atanas G., et al.
Publicado: (2005)

11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia
por: Kosicka, Katarzyna, et al.
Publicado: (2016)

Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega
por: Doden, Heidi L., et al.
Publicado: (2021)

ODP443 Targeting NAD+ availability modulates 11β- Hydroxysteroid dehydrogenase 1 activity in mouse and human cell lines and primary cells
por: Kabli, Ali, et al.
Publicado: (2022)

11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle
por: Morgan, Stuart A., et al.
Publicado: (2009)

Ligand-Based Pharmacophore Modeling and Virtual Screening for the Discovery of Novel 17β-Hydroxysteroid Dehydrogenase 2 Inhibitors
por: Vuorinen, Anna, et al.
Publicado: (2014)

11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo
por: Mitić, Tijana, et al.
Publicado: (2013)

Modulation of 11β-Hydroxysteroid Dehydrogenase as a Strategy to Reduce Vascular Inflammation
por: Hadoke, Patrick W. F., et al.
Publicado: (2013)

Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: Effect of the deciduoma reaction
por: Clementi, Marisa A, et al.
Publicado: (2004)

Irritable bowel syndrome: an approach for primary care physicians
por: Tan, Zhi En, et al.
Publicado: (2022)

Lack of Significant Metabolic Abnormalities in Mice with Liver-Specific Disruption of 11β-Hydroxysteroid Dehydrogenase Type 1
por: Lavery, Gareth G., et al.
Publicado: (2012)

11β‐Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation
por: Hardy, Rowan S, et al.
Publicado: (2016)

Hexose-6-phosphate Dehydrogenase Modulates 11β-Hydroxysteroid Dehydrogenase Type 1-Dependent Metabolism of 7-keto- and 7β-hydroxy-neurosteroids
por: Nashev, Lyubomir G., et al.
Publicado: (2007)

11β-Hydroxysteroid Dehydrogenases and Hypertension in the Metabolic Syndrome
por: Bailey, Matthew A.
Publicado: (2017)

Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin
por: Kim, Beom Jun, et al.
Publicado: (2021)

Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion
por: Keppner, Anna, et al.
Publicado: (2019)

The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity
por: Nakata, Takaya, et al.
Publicado: (2016)

Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2
por: Vuorinen, Anna, et al.
Publicado: (2017)

Cysteine-10 on 17β-Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals
por: Nashev, Lyubomir G., et al.
Publicado: (2013)

Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: An hypothesis
por: Chapman, John C, et al.
Publicado: (2005)

Adrenal morphology and hydroxysteroid dehydrogenase enzymes in normal and intersex goats
por: Basrur, Parvathi K, et al.
Publicado: (1969)

Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases
por: Markey, Keira A, et al.
Publicado: (2016)

Cortisol, Hypertension and Obesity: The Role of 11β-Hydroxysteroid Dehydrogenase
por: Stewart, Paul M
Publicado: (1998)

11β-Hydroxysteroid Dehydrogenase Type 1 within Osteoclasts Mediates the Bone Protective Properties of Therapeutic Corticosteroids in Chronic Inflammation
por: Fenton, Chloe G, et al.
Publicado: (2022)

Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection
por: Weingartner, Michael, et al.
Publicado: (2022)

Central Glucocorticoid Administration Promotes Weight Gain and Increased 11β-Hydroxysteroid Dehydrogenase Type 1 Expression in White Adipose Tissue
por: Veyrat-Durebex, Christelle, et al.
Publicado: (2012)

Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation
por: Chapman, Karen E., et al.
Publicado: (2013)

11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet
por: Johnson, Jethro S, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nin5mueoeurr17e1p2v0volmd3