Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection

We report on a unique case of a 7-year-old girl with new onset ocular myasthenia gravis shortly after recovery from multisystem inflammatory syndrome in children (MIS-C) temporally associated with SARS-CoV-2 infection. The diagnosis of myasthenia gravis was based on suggestive symptoms of fatigable...

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Autores principales: Essajee, Farida, Lishman, Juanita, Solomons, Regan, Abraham, Deepthi Raju, Goussard, Pierre, Van Toorn, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359482/
https://www.ncbi.nlm.nih.gov/pubmed/34380685
http://dx.doi.org/10.1136/bcr-2021-244102
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author Essajee, Farida
Lishman, Juanita
Solomons, Regan
Abraham, Deepthi Raju
Goussard, Pierre
Van Toorn, Ronald
author_facet Essajee, Farida
Lishman, Juanita
Solomons, Regan
Abraham, Deepthi Raju
Goussard, Pierre
Van Toorn, Ronald
author_sort Essajee, Farida
collection PubMed
description We report on a unique case of a 7-year-old girl with new onset ocular myasthenia gravis shortly after recovery from multisystem inflammatory syndrome in children (MIS-C) temporally associated with SARS-CoV-2 infection. The diagnosis of myasthenia gravis was based on suggestive symptoms of fatigable bilateral orbital ptosis, diplopia, positive ocular cold compression test and serum acetylcholine receptor antibody positivity, as well as a favourable treatment response to pyridostigmine. The addition of corticosteroids and methotrexate resulted in complete resolution of the ocular signs.
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spelling pubmed-83594822021-08-30 Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection Essajee, Farida Lishman, Juanita Solomons, Regan Abraham, Deepthi Raju Goussard, Pierre Van Toorn, Ronald BMJ Case Rep Case Report We report on a unique case of a 7-year-old girl with new onset ocular myasthenia gravis shortly after recovery from multisystem inflammatory syndrome in children (MIS-C) temporally associated with SARS-CoV-2 infection. The diagnosis of myasthenia gravis was based on suggestive symptoms of fatigable bilateral orbital ptosis, diplopia, positive ocular cold compression test and serum acetylcholine receptor antibody positivity, as well as a favourable treatment response to pyridostigmine. The addition of corticosteroids and methotrexate resulted in complete resolution of the ocular signs. BMJ Publishing Group 2021-08-11 /pmc/articles/PMC8359482/ /pubmed/34380685 http://dx.doi.org/10.1136/bcr-2021-244102 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
spellingShingle Case Report
Essajee, Farida
Lishman, Juanita
Solomons, Regan
Abraham, Deepthi Raju
Goussard, Pierre
Van Toorn, Ronald
Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection
title Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection
title_full Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection
title_fullStr Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection
title_full_unstemmed Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection
title_short Transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (MIS-C) temporally associated with COVID-19 infection
title_sort transient acetylcholine receptor-related myasthenia gravis, post multisystem inflammatory syndrome in children (mis-c) temporally associated with covid-19 infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359482/
https://www.ncbi.nlm.nih.gov/pubmed/34380685
http://dx.doi.org/10.1136/bcr-2021-244102
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