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COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era
BACKGROUND: Information regarding inborn error of immunity (IEI) as a risk factor for severe COVID-19 is scarce. We aimed to determine if paediatric patients with moderate/severe IEI got COVID-19 at the same level as the general population, and to describe COVID-19 expression. MATERIAL AND METHODS:...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359496/ https://www.ncbi.nlm.nih.gov/pubmed/34391937 http://dx.doi.org/10.1016/j.clim.2021.108821 |
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author | Deyà-Martínez, A. García-García, A. Gonzalez-Navarro, E.A. Yiyi, L. Vlagea, A. Jordan, I. Fumadó, V. Fortuny, C. Español, M. Launes, C. Esteve-Solé, A. Juan, M. Pascal, M. Alsina, L. |
author_facet | Deyà-Martínez, A. García-García, A. Gonzalez-Navarro, E.A. Yiyi, L. Vlagea, A. Jordan, I. Fumadó, V. Fortuny, C. Español, M. Launes, C. Esteve-Solé, A. Juan, M. Pascal, M. Alsina, L. |
author_sort | Deyà-Martínez, A. |
collection | PubMed |
description | BACKGROUND: Information regarding inborn error of immunity (IEI) as a risk factor for severe COVID-19 is scarce. We aimed to determine if paediatric patients with moderate/severe IEI got COVID-19 at the same level as the general population, and to describe COVID-19 expression. MATERIAL AND METHODS: We included patients with moderate/severe IEI aged 0–21 years old: cross-sectional study (June2020) to determine the prevalence of COVID-19; prospective study (January2020-January2021) including IEI patients with COVID-19. Assays used: nasopharyngeal swab SARS-CoV-2 PCR and SARS-CoV-2-specific immunoglobulins. RESULTS: Seven from sixty-five patients tested positive (prevalence: 10.7% (7%–13%)) after the first SARS-COV-2 wave and 13/15 patients diagnosed with COVID-19 had an asymptomatic/mild course. CONCLUSIONS: In our area, prevalence of COVID-19 in moderate/severe IEI paediatric patients after the first wave was slightly higher than in the general population. The majority of patients presented a benign course, suggesting a possible protective factor related with age despite IEI. |
format | Online Article Text |
id | pubmed-8359496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83594962021-08-12 COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era Deyà-Martínez, A. García-García, A. Gonzalez-Navarro, E.A. Yiyi, L. Vlagea, A. Jordan, I. Fumadó, V. Fortuny, C. Español, M. Launes, C. Esteve-Solé, A. Juan, M. Pascal, M. Alsina, L. Clin Immunol Full Length Article BACKGROUND: Information regarding inborn error of immunity (IEI) as a risk factor for severe COVID-19 is scarce. We aimed to determine if paediatric patients with moderate/severe IEI got COVID-19 at the same level as the general population, and to describe COVID-19 expression. MATERIAL AND METHODS: We included patients with moderate/severe IEI aged 0–21 years old: cross-sectional study (June2020) to determine the prevalence of COVID-19; prospective study (January2020-January2021) including IEI patients with COVID-19. Assays used: nasopharyngeal swab SARS-CoV-2 PCR and SARS-CoV-2-specific immunoglobulins. RESULTS: Seven from sixty-five patients tested positive (prevalence: 10.7% (7%–13%)) after the first SARS-COV-2 wave and 13/15 patients diagnosed with COVID-19 had an asymptomatic/mild course. CONCLUSIONS: In our area, prevalence of COVID-19 in moderate/severe IEI paediatric patients after the first wave was slightly higher than in the general population. The majority of patients presented a benign course, suggesting a possible protective factor related with age despite IEI. The Authors. Published by Elsevier Inc. 2021-09 2021-08-12 /pmc/articles/PMC8359496/ /pubmed/34391937 http://dx.doi.org/10.1016/j.clim.2021.108821 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Full Length Article Deyà-Martínez, A. García-García, A. Gonzalez-Navarro, E.A. Yiyi, L. Vlagea, A. Jordan, I. Fumadó, V. Fortuny, C. Español, M. Launes, C. Esteve-Solé, A. Juan, M. Pascal, M. Alsina, L. COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era |
title | COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era |
title_full | COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era |
title_fullStr | COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era |
title_full_unstemmed | COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era |
title_short | COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era |
title_sort | covid-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359496/ https://www.ncbi.nlm.nih.gov/pubmed/34391937 http://dx.doi.org/10.1016/j.clim.2021.108821 |
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