Cargando…

More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing

BACKGROUND: During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic acid (FA...

Descripción completa

Detalles Bibliográficos
Autores principales: Ou, Qianmin, Zhang, Shaohan, Fu, Chuanqiang, Yu, Le, Xin, Peikun, Gu, Zhipeng, Cao, Zeyuan, Wu, Jun, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359571/
https://www.ncbi.nlm.nih.gov/pubmed/34380475
http://dx.doi.org/10.1186/s12951-021-00973-7
_version_ 1783737575386644480
author Ou, Qianmin
Zhang, Shaohan
Fu, Chuanqiang
Yu, Le
Xin, Peikun
Gu, Zhipeng
Cao, Zeyuan
Wu, Jun
Wang, Yan
author_facet Ou, Qianmin
Zhang, Shaohan
Fu, Chuanqiang
Yu, Le
Xin, Peikun
Gu, Zhipeng
Cao, Zeyuan
Wu, Jun
Wang, Yan
author_sort Ou, Qianmin
collection PubMed
description BACKGROUND: During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic acid (FA) are natural compounds derived from herbs that exhibit multiple pharmacological activities, such as antioxidant and anti-inflammatory effects. Polydopamine (PDA) is made from natural dopamine and shows excellent antioxidant function. Therefore, the combination of natural antioxidants into hydrogel dressing is a promising therapy for wound healing. RESULTS: Hydrogel wound dressings have been developed by incorporating PUE or FA via PDA nanoparticles (NPs) into polyethylene glycol diacrylate (PEG-DA) hydrogel. This hydrogel can load natural antioxidant drugs and retain the drug in the gel network for a long period due to the presence of PDA NPs. Under oxidative stress, this hydrogel can improve the activity of superoxide dismutase and glutathione peroxidase and reduce the levels of ROS and malondialdehyde, thus preventing oxidative damage to cells, and then promoting wound healing, tissue regeneration, and collagen accumulation. CONCLUSION: Overall, this triple antioxidant hydrogel accelerates wound healing by alleviating oxidative injury. Our study thus provides a new way about co-delivery of multiple antioxidant natural molecules from herbs via antioxidant nanoparticles for wound healing and skin regeneration. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-021-00973-7.
format Online
Article
Text
id pubmed-8359571
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-83595712021-08-16 More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing Ou, Qianmin Zhang, Shaohan Fu, Chuanqiang Yu, Le Xin, Peikun Gu, Zhipeng Cao, Zeyuan Wu, Jun Wang, Yan J Nanobiotechnology Research BACKGROUND: During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic acid (FA) are natural compounds derived from herbs that exhibit multiple pharmacological activities, such as antioxidant and anti-inflammatory effects. Polydopamine (PDA) is made from natural dopamine and shows excellent antioxidant function. Therefore, the combination of natural antioxidants into hydrogel dressing is a promising therapy for wound healing. RESULTS: Hydrogel wound dressings have been developed by incorporating PUE or FA via PDA nanoparticles (NPs) into polyethylene glycol diacrylate (PEG-DA) hydrogel. This hydrogel can load natural antioxidant drugs and retain the drug in the gel network for a long period due to the presence of PDA NPs. Under oxidative stress, this hydrogel can improve the activity of superoxide dismutase and glutathione peroxidase and reduce the levels of ROS and malondialdehyde, thus preventing oxidative damage to cells, and then promoting wound healing, tissue regeneration, and collagen accumulation. CONCLUSION: Overall, this triple antioxidant hydrogel accelerates wound healing by alleviating oxidative injury. Our study thus provides a new way about co-delivery of multiple antioxidant natural molecules from herbs via antioxidant nanoparticles for wound healing and skin regeneration. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-021-00973-7. BioMed Central 2021-08-11 /pmc/articles/PMC8359571/ /pubmed/34380475 http://dx.doi.org/10.1186/s12951-021-00973-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ou, Qianmin
Zhang, Shaohan
Fu, Chuanqiang
Yu, Le
Xin, Peikun
Gu, Zhipeng
Cao, Zeyuan
Wu, Jun
Wang, Yan
More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing
title More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing
title_full More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing
title_fullStr More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing
title_full_unstemmed More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing
title_short More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing
title_sort more natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359571/
https://www.ncbi.nlm.nih.gov/pubmed/34380475
http://dx.doi.org/10.1186/s12951-021-00973-7
work_keys_str_mv AT ouqianmin morenaturalmorebettertriplenaturalantioxidantpuerarinferulicacidpolydopamineincorporatedhydrogelforwoundhealing
AT zhangshaohan morenaturalmorebettertriplenaturalantioxidantpuerarinferulicacidpolydopamineincorporatedhydrogelforwoundhealing
AT fuchuanqiang morenaturalmorebettertriplenaturalantioxidantpuerarinferulicacidpolydopamineincorporatedhydrogelforwoundhealing
AT yule morenaturalmorebettertriplenaturalantioxidantpuerarinferulicacidpolydopamineincorporatedhydrogelforwoundhealing
AT xinpeikun morenaturalmorebettertriplenaturalantioxidantpuerarinferulicacidpolydopamineincorporatedhydrogelforwoundhealing
AT guzhipeng morenaturalmorebettertriplenaturalantioxidantpuerarinferulicacidpolydopamineincorporatedhydrogelforwoundhealing
AT caozeyuan morenaturalmorebettertriplenaturalantioxidantpuerarinferulicacidpolydopamineincorporatedhydrogelforwoundhealing
AT wujun morenaturalmorebettertriplenaturalantioxidantpuerarinferulicacidpolydopamineincorporatedhydrogelforwoundhealing
AT wangyan morenaturalmorebettertriplenaturalantioxidantpuerarinferulicacidpolydopamineincorporatedhydrogelforwoundhealing