MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers

The incidence of bicuspid aortic valves (BAV) is high in the whole population, BAV-related thoracic aortic aneurysm (TAA) is accompanied by many adverse vascular events. So far, there are two key points in dealing with BAV-related TAA. First is fully understanding on its pathogenesis. Second is opti...

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Autores principales: Jia, Hao, Kang, Le, Ma, Zhen, Lu, Shuyang, Huang, Ben, Wang, Chunsheng, Zou, Yunzeng, Sun, Yongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359579/
https://www.ncbi.nlm.nih.gov/pubmed/34384454
http://dx.doi.org/10.1186/s13019-021-01613-9
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author Jia, Hao
Kang, Le
Ma, Zhen
Lu, Shuyang
Huang, Ben
Wang, Chunsheng
Zou, Yunzeng
Sun, Yongxin
author_facet Jia, Hao
Kang, Le
Ma, Zhen
Lu, Shuyang
Huang, Ben
Wang, Chunsheng
Zou, Yunzeng
Sun, Yongxin
author_sort Jia, Hao
collection PubMed
description The incidence of bicuspid aortic valves (BAV) is high in the whole population, BAV-related thoracic aortic aneurysm (TAA) is accompanied by many adverse vascular events. So far, there are two key points in dealing with BAV-related TAA. First is fully understanding on its pathogenesis. Second is optimizing surgical intervention time. This review aims to illustrate the potential role of miRNAs in both aspects, that is, how miRNAs are involved in the occurrence and progression of BAV-related TAA, and the feasibilities of miRNAs as biomarkers.
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spelling pubmed-83595792021-08-16 MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers Jia, Hao Kang, Le Ma, Zhen Lu, Shuyang Huang, Ben Wang, Chunsheng Zou, Yunzeng Sun, Yongxin J Cardiothorac Surg Review The incidence of bicuspid aortic valves (BAV) is high in the whole population, BAV-related thoracic aortic aneurysm (TAA) is accompanied by many adverse vascular events. So far, there are two key points in dealing with BAV-related TAA. First is fully understanding on its pathogenesis. Second is optimizing surgical intervention time. This review aims to illustrate the potential role of miRNAs in both aspects, that is, how miRNAs are involved in the occurrence and progression of BAV-related TAA, and the feasibilities of miRNAs as biomarkers. BioMed Central 2021-08-12 /pmc/articles/PMC8359579/ /pubmed/34384454 http://dx.doi.org/10.1186/s13019-021-01613-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Jia, Hao
Kang, Le
Ma, Zhen
Lu, Shuyang
Huang, Ben
Wang, Chunsheng
Zou, Yunzeng
Sun, Yongxin
MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers
title MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers
title_full MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers
title_fullStr MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers
title_full_unstemmed MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers
title_short MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers
title_sort micrornas involve in bicuspid aortic aneurysm: pathogenesis and biomarkers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359579/
https://www.ncbi.nlm.nih.gov/pubmed/34384454
http://dx.doi.org/10.1186/s13019-021-01613-9
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