Can large doses of glucocorticoids lead to Perthes? a case report and review of the literature

BACKGROUND: Perthes disease (Legg-Calvé-Perthes, LCP) is a self-limited and non-systemic disease occurring in the femoral heads of children, which is mainly manifested as an ischemic necrosis of the femoral head epiphysis, leading to subchondral ossification injury of the femoral head. CASE PRESENTA...

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Autores principales: Chen, Guoming, Chen, Tengyu, Zhang, Peng, Zhang, Zhaoping, Huang, Ruilan, Chen, Tao, He, Wei, Wang, Haibin, Zhou, Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359607/
https://www.ncbi.nlm.nih.gov/pubmed/34384372
http://dx.doi.org/10.1186/s12887-021-02755-4
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author Chen, Guoming
Chen, Tengyu
Zhang, Peng
Zhang, Zhaoping
Huang, Ruilan
Chen, Tao
He, Wei
Wang, Haibin
Zhou, Chi
author_facet Chen, Guoming
Chen, Tengyu
Zhang, Peng
Zhang, Zhaoping
Huang, Ruilan
Chen, Tao
He, Wei
Wang, Haibin
Zhou, Chi
author_sort Chen, Guoming
collection PubMed
description BACKGROUND: Perthes disease (Legg-Calvé-Perthes, LCP) is a self-limited and non-systemic disease occurring in the femoral heads of children, which is mainly manifested as an ischemic necrosis of the femoral head epiphysis, leading to subchondral ossification injury of the femoral head. CASE PRESENTATION: Here we report a case of 11-year-old child with long-term use of high-dose glucocorticoids. With MRI examination finding the epiphyseal necrosis of right humeral head, femur and tibia, and X-ray examination finding bilateral femoral head necrosis, the child was diagnosed as Perthes disease based on his clinical and imaging data. CONCLUSIONS: Long-term and high-dose glucocorticoids may be one of the causes of Perthes disease.
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spelling pubmed-83596072021-08-16 Can large doses of glucocorticoids lead to Perthes? a case report and review of the literature Chen, Guoming Chen, Tengyu Zhang, Peng Zhang, Zhaoping Huang, Ruilan Chen, Tao He, Wei Wang, Haibin Zhou, Chi BMC Pediatr Case Report BACKGROUND: Perthes disease (Legg-Calvé-Perthes, LCP) is a self-limited and non-systemic disease occurring in the femoral heads of children, which is mainly manifested as an ischemic necrosis of the femoral head epiphysis, leading to subchondral ossification injury of the femoral head. CASE PRESENTATION: Here we report a case of 11-year-old child with long-term use of high-dose glucocorticoids. With MRI examination finding the epiphyseal necrosis of right humeral head, femur and tibia, and X-ray examination finding bilateral femoral head necrosis, the child was diagnosed as Perthes disease based on his clinical and imaging data. CONCLUSIONS: Long-term and high-dose glucocorticoids may be one of the causes of Perthes disease. BioMed Central 2021-08-12 /pmc/articles/PMC8359607/ /pubmed/34384372 http://dx.doi.org/10.1186/s12887-021-02755-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Chen, Guoming
Chen, Tengyu
Zhang, Peng
Zhang, Zhaoping
Huang, Ruilan
Chen, Tao
He, Wei
Wang, Haibin
Zhou, Chi
Can large doses of glucocorticoids lead to Perthes? a case report and review of the literature
title Can large doses of glucocorticoids lead to Perthes? a case report and review of the literature
title_full Can large doses of glucocorticoids lead to Perthes? a case report and review of the literature
title_fullStr Can large doses of glucocorticoids lead to Perthes? a case report and review of the literature
title_full_unstemmed Can large doses of glucocorticoids lead to Perthes? a case report and review of the literature
title_short Can large doses of glucocorticoids lead to Perthes? a case report and review of the literature
title_sort can large doses of glucocorticoids lead to perthes? a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359607/
https://www.ncbi.nlm.nih.gov/pubmed/34384372
http://dx.doi.org/10.1186/s12887-021-02755-4
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