Cargando…

An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum

BACKGROUND: Plasmodium falciparum is the pathogen responsible for the most devastating form of human malaria. As it replicates asexually in the erythrocytes of its human host, the parasite feeds on haemoglobin uptaken from these cells. Heme, a toxic by-product of haemoglobin utilization by the paras...

Descripción completa

Detalles Bibliográficos
Autores principales:	Asad, Mohd, Yamaryo-Botté, Yoshiki, Hossain, Mohammad E., Thakur, Vandana, Jain, Shaifali, Datta, Gaurav, Botté, Cyrille Y., Mohmmed, Asif
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359613/ https://www.ncbi.nlm.nih.gov/pubmed/34380472 http://dx.doi.org/10.1186/s12915-021-01042-z

Ejemplares similares

Protein kinase TgCDPK7 regulates vesicular trafficking and phospholipid synthesis in Toxoplasma gondii
por: Bansal, Priyanka, et al.
Publicado: (2021)

Variation in Lipid Species Profiles among Leukemic Cells Significantly Impacts Their Sensitivity to the Drug Targeting of Lipid Metabolism and the Prognosis of AML Patients
por: Lo Presti, Caroline, et al.
Publicado: (2023)

Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability
por: Renaud, Eléa A., et al.
Publicado: (2022)

Dual role of an essential HtrA2/Omi protease in the human malaria parasite: Maintenance of mitochondrial homeostasis and induction of apoptosis-like cell death under cellular stress
por: Singh, Shweta, et al.
Publicado: (2022)

Intraleukocytic hemozoin pigments in complicated Plasmodium falciparum cerebral malaria
por: Sultan, Sadia, et al.
Publicado: (2015)

Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
por: Dass, Sheena, et al.
Publicado: (2021)

Fatty Acid Profiles of Leishmania major Derived from Human and Rodent Hosts in Endemic Cutaneous Leishmaniasis Areas of Tunisia and Algeria
por: Bouabid, Cyrine, et al.
Publicado: (2022)

Intracytoplasmic Hemozoin (Malarial Pigment) in a Case of Severe, Aparasitemic Plasmodium falciparum Malaria
por: Grande, Romualdo, et al.
Publicado: (2011)

Identification of Plant-like Galactolipids in Chromera velia, a Photosynthetic Relative of Malaria Parasites
por: Botté, Cyrille Y., et al.
Publicado: (2011)

CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells
por: Krishnamurthy, Shruthi, et al.
Publicado: (2023)

Heme Detoxification Protein ( PfHDP) is essential for the hemoglobin uptake and metabolism in Plasmodium falciparum
por: Gupta, Priya, et al.
Publicado: (2022)

Quantitative characterization of hemozoin in Plasmodium berghei and vivax
por: Pisciotta, John M., et al.
Publicado: (2017)

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1
por: Vanwalleghem, Gilles, et al.
Publicado: (2015)

A Novel Flow Cytometric Hemozoin Detection Assay for Real-Time Sensitivity Testing of Plasmodium falciparum
por: Rebelo, Maria, et al.
Publicado: (2013)

Trafficked Proteins—Druggable in Plasmodium falciparum?
por: Lindner, Jasmin, et al.
Publicado: (2013)

Genome wide in silico analysis of Plasmodium falciparum phosphatome
por: Pandey, Rajan, et al.
Publicado: (2014)

Identification of Essential Histidine Residues Involved in Heme Binding and Hemozoin Formation in Heme Detoxification Protein from Plasmodium falciparum
por: Nakatani, Keisuke, et al.
Publicado: (2014)

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase
por: Amiar, Souad, et al.
Publicado: (2016)

Etymologia: Hemozoin
Publicado: (2016)

In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice
por: Frita, Rosangela, et al.
Publicado: (2012)

2-Phenoxy-3-Trichloromethylquinoxalines Are Antiplasmodial Derivatives with Activity against the Apicoplast of Plasmodium falciparum
por: Amrane, Dyhia, et al.
Publicado: (2021)

Characterization of the Plasmodium falciparum and P. berghei glycerol 3‐phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast
por: Shears, Melanie J., et al.
Publicado: (2016)

Identification and Characterization of a Novel Plasmodium falciparum Merozoite Apical Protein Involved in Erythrocyte Binding and Invasion
por: Wickramarachchi, Thilan, et al.
Publicado: (2008)

A systematic classification of Plasmodium falciparum P-loop NTPases: structural and functional correlation
por: Gangwar, Deepti, et al.
Publicado: (2009)

Plasmodium vivax Tryptophan Rich Antigen PvTRAg36.6 Interacts with PvETRAMP and PvTRAg56.6 Interacts with PvMSP7 during Erythrocytic Stages of the Parasite
por: Tyagi, Kriti, et al.
Publicado: (2016)

Heterologous expression in Toxoplasma gondii reveals a topogenic signal anchor in a Plasmodium apicoplast protein
por: Narayan, Aishwarya, et al.
Publicado: (2018)

Quinoline-triazole hybrids inhibit falcipain-2 and arrest the development of Plasmodium falciparum at the trophozoite stage
por: Singh, Anju, et al.
Publicado: (2019)

Superparamagnetic Properties of Hemozoin
por: Inyushin, M., et al.
Publicado: (2016)

Uptake of Plasmodium chabaudi hemozoin drives Kupffer cell death and fuels superinfections
por: Hirako, Isabella C., et al.
Publicado: (2022)

Widespread occurrence of lysine methylation in Plasmodium falciparum proteins at asexual blood stages
por: Kaur, Inderjeet, et al.
Publicado: (2016)

Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor
por: Rottmann, Matthias, et al.
Publicado: (2020)

The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity
por: Lecordier, Laurence, et al.
Publicado: (2020)

Synthetic Plasmodium-Like Hemozoin Activates the Immune Response: A Morphology - Function Study
por: Jaramillo, Maritza, et al.
Publicado: (2009)

Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance
por: Lin, Jing-wen, et al.
Publicado: (2015)

Hemozoin activates the innate immune system and reduces Plasmodium berghei infection in Anopheles gambiae
por: Simões, Maria L, et al.
Publicado: (2015)

Phospholipid Membrane-Mediated Hemozoin Formation: The Effects of Physical Properties and Evidence of Membrane Surrounding Hemozoin
por: Huy, Nguyen Tien, et al.
Publicado: (2013)

Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation
por: Burda, Paul-Christian, et al.
Publicado: (2023)

A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL‐NTD database blocks parasite growth
por: Pandey, Rajan, et al.
Publicado: (2021)

Correction: Synthetic Plasmodium-Like Hemozoin Activates the Immune Response: A Morphology - Function Study
por: Jaramillo, Maritza, et al.
Publicado: (2009)

Evidence for the Contribution of the Hemozoin Synthesis Pathway of the Murine Plasmodium yoelii to the Resistance to Artemisinin-Related Drugs
por: Witkowski, Benoit, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cf2llnh4shebmkoqdsukg53f1a