Cargando…

Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms

Detalles Bibliográficos
Autores principales:	Hoertel, Nicolas, Sánchez-Rico, Marina, Cougoule, Céline, Gulbins, Erich, Kornhuber, Johannes, Carpinteiro, Alexander, Becker, Katrin Anne, Reiersen, Angela M., Lenze, Eric J., Seftel, David, Lemogne, Cédric, Limosin, Frédéric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Correspondence
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359627/ https://www.ncbi.nlm.nih.gov/pubmed/34385600 http://dx.doi.org/10.1038/s41380-021-01254-3

Ejemplares similares

Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational Study
por: Hoertel, Nicolas, et al.
Publicado: (2023)

The acid sphingomyelinase/ceramide system in COVID-19
por: Kornhuber, Johannes, et al.
Publicado: (2021)

Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2: Support for the FIASMA Model against COVID-19
por: Hoertel, Nicolas, et al.
Publicado: (2022)

Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2: Support for the FIASMA Model against COVID-19
por: Hoertel, N., et al.
Publicado: (2023)

Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality: Results from 49,089 COVID-19 inpatients
por: Hoertel, Nicolas, et al.
Publicado: (2021)

Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
por: Carpinteiro, Alexander, et al.
Publicado: (2021)

Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID‐19: An Observational Multicenter Study
por: Hoertel, Nicolas, et al.
Publicado: (2021)

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons
por: Beckmann, Nadine, et al.
Publicado: (2014)

Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders: An Observational Multicenter Study in France
por: Hoertel, Nicolas, et al.
Publicado: (2022)

Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
por: Schumacher, Fabian, et al.
Publicado: (2022)

Association between FIASMA psychotropic medications and reduced risk of intubation or death in individuals with psychiatric disorders hospitalized for severe COVID-19: an observational multicenter study
por: Hoertel, Nicolas, et al.
Publicado: (2022)

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
por: Gulbins, Anne, et al.
Publicado: (2018)

Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory
por: Zoicas, Iulia, et al.
Publicado: (2016)

DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells
por: Avota, Elita, et al.
Publicado: (2011)

Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model
por: Péricat, David, et al.
Publicado: (2022)

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease
por: Beckmann, Nadine, et al.
Publicado: (2019)

Association between benzodiazepine receptor agonist use and mortality in patients hospitalised for COVID-19: a multicentre observational study
por: Hoertel, N., et al.
Publicado: (2022)

Differential Activation of Acid Sphingomyelinase and Ceramide Release Determines Invasiveness of Neisseria meningitidis into Brain Endothelial Cells
por: Simonis, Alexander, et al.
Publicado: (2014)

Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
por: Wilson, Gregory C., et al.
Publicado: (2023)

Regulation of hematogenous tumor metastasis by acid sphingomyelinase
por: Carpinteiro, Alexander, et al.
Publicado: (2015)

New Molecular Targets for Antidepressant Drugs
por: Kornhuber, Johannes, et al.
Publicado: (2021)

mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment
por: Rhein, Cosima, et al.
Publicado: (2021)

Association between antidepressant use and ED or hospital visits in outpatients with SARS-CoV-2
por: Fritz, Bradley A., et al.
Publicado: (2022)

Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation
por: Reichel, Martin, et al.
Publicado: (2018)

Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
por: Carpinteiro, Alexander, et al.
Publicado: (2020)

Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase
por: Managò, Antonella, et al.
Publicado: (2015)

Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cells
por: Becker, Katrin Anne, et al.
Publicado: (2021)

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro
por: Naser, Eyad, et al.
Publicado: (2020)

Characterization of Acid Sphingomyelinase Activity in Human Cerebrospinal Fluid
por: Mühle, Christiane, et al.
Publicado: (2013)

Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy Controls
por: Mühle, Christiane, et al.
Publicado: (2018)

The Role of Sphingolipids and Ceramide in Pulmonary Inflammation in Cystic Fibrosis
por: Becker, Katrin Anne, et al.
Publicado: (2010)

Outcomes associated with antidepressant treatment according to the number of prescriptions and treatment changes: 5-year follow-up of a nation-wide cohort study
por: Ouazana-Vedrines, Charles, et al.
Publicado: (2022)

Job exposure to the public in relation with alcohol, tobacco and cannabis use: Findings from the CONSTANCES cohort study
por: Airagnes, Guillaume, et al.
Publicado: (2018)

Towards quantifying the reciprocal associations between frequency of cannabis use and alcohol consumption: a cross-lagged analysis from the CONSTANCES cohort
por: Airagnes, Guillaume, et al.
Publicado: (2022)

Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis
por: Müller, Christian P., et al.
Publicado: (2016)

Secretory Acid Sphingomyelinase in the Serum of Medicated Patients Predicts the Prospective Course of Depression
por: Mühle, Christiane, et al.
Publicado: (2019)

The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice
por: Zoicas, Iulia, et al.
Publicado: (2020)

Retirement age does not modify the association of prior working conditions with self-rated health and mortality in retirees: results from a prospective study of retired French workers
por: Hoertel, Nicolas, et al.
Publicado: (2022)

Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants
por: Rhein, Cosima, et al.
Publicado: (2012)

Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model
por: Péricat, D., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_flr9attpbgi6tr3f26vhn0gohm