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Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase?

Background: As with other inflammatory diseases, the (dry) cough in COVID-19 patients indicates that mucociliary clearance (MCC) is at least at risk, if not overloaded, damaged or largely inoperable. Coughing is an important secondary mechanism that only takes over bronchial cleansing as a replaceme...

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Autor principal: Wittig, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Medizin 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359637/
https://www.ncbi.nlm.nih.gov/pubmed/34383284
http://dx.doi.org/10.1007/s15006-021-0189-9
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author Wittig, Thomas
author_facet Wittig, Thomas
author_sort Wittig, Thomas
collection PubMed
description Background: As with other inflammatory diseases, the (dry) cough in COVID-19 patients indicates that mucociliary clearance (MCC) is at least at risk, if not overloaded, damaged or largely inoperable. Coughing is an important secondary mechanism that only takes over bronchial cleansing as a replacement if the MCC has failed. Method: The review article describes the physiology and pathophysiology of MCC and its possible role in the pathogenesis of COVID-19. Results and Conclusions: Human and animal studies as well as autopsy reports indicate that MCC could also be important for the COVID-19 pathogenesis. In primary care, MCC plays a major role in inflammatory respiratory diseases. In Germany, drugs for self-medication are approved for treatment and, due to the high quality of studies, are also recommended in the respective guidelines. A symptomatic approach to stabilize the airway barrier would also be conceivable in the early outpatient phase of COVID-19.
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spelling pubmed-83596372021-08-13 Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase? Wittig, Thomas MMW Fortschr Med FB_Übersicht Background: As with other inflammatory diseases, the (dry) cough in COVID-19 patients indicates that mucociliary clearance (MCC) is at least at risk, if not overloaded, damaged or largely inoperable. Coughing is an important secondary mechanism that only takes over bronchial cleansing as a replacement if the MCC has failed. Method: The review article describes the physiology and pathophysiology of MCC and its possible role in the pathogenesis of COVID-19. Results and Conclusions: Human and animal studies as well as autopsy reports indicate that MCC could also be important for the COVID-19 pathogenesis. In primary care, MCC plays a major role in inflammatory respiratory diseases. In Germany, drugs for self-medication are approved for treatment and, due to the high quality of studies, are also recommended in the respective guidelines. A symptomatic approach to stabilize the airway barrier would also be conceivable in the early outpatient phase of COVID-19. Springer Medizin 2021-09-09 2021 /pmc/articles/PMC8359637/ /pubmed/34383284 http://dx.doi.org/10.1007/s15006-021-0189-9 Text en © Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle FB_Übersicht
Wittig, Thomas
Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase?
title Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase?
title_full Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase?
title_fullStr Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase?
title_full_unstemmed Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase?
title_short Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase?
title_sort mukoziliäre clearance bei covid-19-erkrankungen: ein unterschätztes gefahrengebiet in der frühphase?
topic FB_Übersicht
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359637/
https://www.ncbi.nlm.nih.gov/pubmed/34383284
http://dx.doi.org/10.1007/s15006-021-0189-9
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