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Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase?
Background: As with other inflammatory diseases, the (dry) cough in COVID-19 patients indicates that mucociliary clearance (MCC) is at least at risk, if not overloaded, damaged or largely inoperable. Coughing is an important secondary mechanism that only takes over bronchial cleansing as a replaceme...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Medizin
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359637/ https://www.ncbi.nlm.nih.gov/pubmed/34383284 http://dx.doi.org/10.1007/s15006-021-0189-9 |
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author | Wittig, Thomas |
author_facet | Wittig, Thomas |
author_sort | Wittig, Thomas |
collection | PubMed |
description | Background: As with other inflammatory diseases, the (dry) cough in COVID-19 patients indicates that mucociliary clearance (MCC) is at least at risk, if not overloaded, damaged or largely inoperable. Coughing is an important secondary mechanism that only takes over bronchial cleansing as a replacement if the MCC has failed. Method: The review article describes the physiology and pathophysiology of MCC and its possible role in the pathogenesis of COVID-19. Results and Conclusions: Human and animal studies as well as autopsy reports indicate that MCC could also be important for the COVID-19 pathogenesis. In primary care, MCC plays a major role in inflammatory respiratory diseases. In Germany, drugs for self-medication are approved for treatment and, due to the high quality of studies, are also recommended in the respective guidelines. A symptomatic approach to stabilize the airway barrier would also be conceivable in the early outpatient phase of COVID-19. |
format | Online Article Text |
id | pubmed-8359637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Medizin |
record_format | MEDLINE/PubMed |
spelling | pubmed-83596372021-08-13 Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase? Wittig, Thomas MMW Fortschr Med FB_Übersicht Background: As with other inflammatory diseases, the (dry) cough in COVID-19 patients indicates that mucociliary clearance (MCC) is at least at risk, if not overloaded, damaged or largely inoperable. Coughing is an important secondary mechanism that only takes over bronchial cleansing as a replacement if the MCC has failed. Method: The review article describes the physiology and pathophysiology of MCC and its possible role in the pathogenesis of COVID-19. Results and Conclusions: Human and animal studies as well as autopsy reports indicate that MCC could also be important for the COVID-19 pathogenesis. In primary care, MCC plays a major role in inflammatory respiratory diseases. In Germany, drugs for self-medication are approved for treatment and, due to the high quality of studies, are also recommended in the respective guidelines. A symptomatic approach to stabilize the airway barrier would also be conceivable in the early outpatient phase of COVID-19. Springer Medizin 2021-09-09 2021 /pmc/articles/PMC8359637/ /pubmed/34383284 http://dx.doi.org/10.1007/s15006-021-0189-9 Text en © Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | FB_Übersicht Wittig, Thomas Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase? |
title | Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase? |
title_full | Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase? |
title_fullStr | Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase? |
title_full_unstemmed | Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase? |
title_short | Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase? |
title_sort | mukoziliäre clearance bei covid-19-erkrankungen: ein unterschätztes gefahrengebiet in der frühphase? |
topic | FB_Übersicht |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359637/ https://www.ncbi.nlm.nih.gov/pubmed/34383284 http://dx.doi.org/10.1007/s15006-021-0189-9 |
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