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Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study
The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been suggested to be common after SARS-CoV-2 infection, but other components of ANS fu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359764/ https://www.ncbi.nlm.nih.gov/pubmed/34386903 http://dx.doi.org/10.1007/s00415-021-10735-y |
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author | Buoite Stella, Alex Furlanis, Giovanni Frezza, Nicolò Arjuna Valentinotti, Romina Ajcevic, Milos Manganotti, Paolo |
author_facet | Buoite Stella, Alex Furlanis, Giovanni Frezza, Nicolò Arjuna Valentinotti, Romina Ajcevic, Milos Manganotti, Paolo |
author_sort | Buoite Stella, Alex |
collection | PubMed |
description | The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been suggested to be common after SARS-CoV-2 infection, but other components of ANS function may be also impaired. The Composite Autonomic Symptom Scale 31 (COMPASS-31) questionnaire is a simple and validated tool to assess dysautonomic symptoms. The aim of the present study was to administer the COMPASS-31 questionnaire to a sample of post-COVID patients with and without neurological complaints. Participants were recruited among the post-COVID ambulatory services for follow-up evaluation between 4 weeks and 9 months from COVID-19 symptoms onset. Participants were asked to complete the COMPASS-31 questionnaire referring to the period after COVID-19 disease. Heart rate and blood pressure were manually taken during an active stand test for OH and POTS diagnosis. One-hundred and eighty participants were included in the analysis (70.6% females, 51 ± 13 years), and OH was found in 13.8% of the subjects. Median COMPASS-31 score was 17.6 (6.9–31.4), with the most affected domains being orthostatic intolerance, sudomotor, gastrointestinal and pupillomotor dysfunction. A higher COMPASS-31 score was found in those with neurological symptoms (p < 0.01), due to more severe orthostatic intolerance symptoms (p < 0.01), although gastrointestinal (p < 0.01), urinary (p < 0.01), and pupillomotor (p < 0.01) domains were more represented in the non-neurological symptoms group. This study confirms the importance of monitoring ANS symptoms as a possible complication of COVID-19 disease that may persist in the post-acute period. |
format | Online Article Text |
id | pubmed-8359764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-83597642021-08-13 Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study Buoite Stella, Alex Furlanis, Giovanni Frezza, Nicolò Arjuna Valentinotti, Romina Ajcevic, Milos Manganotti, Paolo J Neurol Original Communication The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been suggested to be common after SARS-CoV-2 infection, but other components of ANS function may be also impaired. The Composite Autonomic Symptom Scale 31 (COMPASS-31) questionnaire is a simple and validated tool to assess dysautonomic symptoms. The aim of the present study was to administer the COMPASS-31 questionnaire to a sample of post-COVID patients with and without neurological complaints. Participants were recruited among the post-COVID ambulatory services for follow-up evaluation between 4 weeks and 9 months from COVID-19 symptoms onset. Participants were asked to complete the COMPASS-31 questionnaire referring to the period after COVID-19 disease. Heart rate and blood pressure were manually taken during an active stand test for OH and POTS diagnosis. One-hundred and eighty participants were included in the analysis (70.6% females, 51 ± 13 years), and OH was found in 13.8% of the subjects. Median COMPASS-31 score was 17.6 (6.9–31.4), with the most affected domains being orthostatic intolerance, sudomotor, gastrointestinal and pupillomotor dysfunction. A higher COMPASS-31 score was found in those with neurological symptoms (p < 0.01), due to more severe orthostatic intolerance symptoms (p < 0.01), although gastrointestinal (p < 0.01), urinary (p < 0.01), and pupillomotor (p < 0.01) domains were more represented in the non-neurological symptoms group. This study confirms the importance of monitoring ANS symptoms as a possible complication of COVID-19 disease that may persist in the post-acute period. Springer Berlin Heidelberg 2021-08-12 2022 /pmc/articles/PMC8359764/ /pubmed/34386903 http://dx.doi.org/10.1007/s00415-021-10735-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Communication Buoite Stella, Alex Furlanis, Giovanni Frezza, Nicolò Arjuna Valentinotti, Romina Ajcevic, Milos Manganotti, Paolo Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study |
title | Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study |
title_full | Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study |
title_fullStr | Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study |
title_full_unstemmed | Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study |
title_short | Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study |
title_sort | autonomic dysfunction in post-covid patients with and witfhout neurological symptoms: a prospective multidomain observational study |
topic | Original Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359764/ https://www.ncbi.nlm.nih.gov/pubmed/34386903 http://dx.doi.org/10.1007/s00415-021-10735-y |
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