LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use. We previously developed LIT01-196, a systemically active metabolically stable apelin-17 analog, p...

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Detalles Bibliográficos
Autores principales: Flahault, Adrien, Keck, Mathilde, Girault-Sotias, Pierre-Emmanuel, Esteoulle, Lucie, De Mota, Nadia, Bonnet, Dominique, Llorens-Cortes, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359812/
https://www.ncbi.nlm.nih.gov/pubmed/34393794
http://dx.doi.org/10.3389/fphar.2021.715095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359812/
https://www.ncbi.nlm.nih.gov/pubmed/34393794
http://dx.doi.org/10.3389/fphar.2021.715095

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