High Regio‐ and Stereoselective Multi‐enzymatic Synthesis of All Phenylpropanolamine Stereoisomers from β‐Methylstyrene

We present a one‐pot cascade for the synthesis of phenylpropanolamines (PPAs) in high optical purities (er and dr up to >99.5 %) and analytical yields (up to 95 %) by using 1‐phenylpropane‐1,2‐diols as key intermediates. This bioamination entails the combination of an alcohol dehydrogenase (ADH),...

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Detalles Bibliográficos
Autores principales: Corrado, Maria L., Knaus, Tanja, Mutti, Francesco G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359840/
https://www.ncbi.nlm.nih.gov/pubmed/33880862
http://dx.doi.org/10.1002/cbic.202100123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359840/
https://www.ncbi.nlm.nih.gov/pubmed/33880862
http://dx.doi.org/10.1002/cbic.202100123

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