Cargando…

Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder

BACKGROUND: Parkinson's disease (PD) patients exhibit deficits in saccade performance, pupil function, and blink rate. Isolated REM (rapid eye movement) Sleep Behavior Disorder (RBD) is a harbinger to PD making them candidates to investigate for early oculomotor abnormalities as PD biomarkers....

Descripción completa

Detalles Bibliográficos
Autores principales: Perkins, Julia E., Janzen, Annette, Bernhard, Felix P., Wilhelm, Karén, Brien, Donald C., Huang, Jeff, Coe, Brian C., Vadasz, David, Mayer, Geert, Munoz, Douglas P., Oertel, Wolfgang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359943/
https://www.ncbi.nlm.nih.gov/pubmed/33754406
http://dx.doi.org/10.1002/mds.28585
_version_ 1783737640617508864
author Perkins, Julia E.
Janzen, Annette
Bernhard, Felix P.
Wilhelm, Karén
Brien, Donald C.
Huang, Jeff
Coe, Brian C.
Vadasz, David
Mayer, Geert
Munoz, Douglas P.
Oertel, Wolfgang H.
author_facet Perkins, Julia E.
Janzen, Annette
Bernhard, Felix P.
Wilhelm, Karén
Brien, Donald C.
Huang, Jeff
Coe, Brian C.
Vadasz, David
Mayer, Geert
Munoz, Douglas P.
Oertel, Wolfgang H.
author_sort Perkins, Julia E.
collection PubMed
description BACKGROUND: Parkinson's disease (PD) patients exhibit deficits in saccade performance, pupil function, and blink rate. Isolated REM (rapid eye movement) Sleep Behavior Disorder (RBD) is a harbinger to PD making them candidates to investigate for early oculomotor abnormalities as PD biomarkers. OBJECTIVES: We tested whether saccade, pupillary, and blink responses in RBD were similar to PD. METHODS: RBD (n = 22), PD (n = 22) patients, and healthy controls (CTRL) (n = 74) were studied with video‐based eye‐tracking. RESULTS: RBD patients did not have significantly different saccadic behavior compared to CTRL, but PD patients differed from CTRL and RBD. Both patient groups had significantly lower blink rates, dampened pupil constriction, and dilation responses compared to CTRL. CONCLUSION: RBD and PD patients had altered pupil and blink behavior compared to CTRL. Because RBD saccade parameters were comparable to CTRL, pupil and blink brain areas may be impacted before saccadic control areas, making them potential prodromal PD biomarkers. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
format Online
Article
Text
id pubmed-8359943
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-83599432021-08-17 Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder Perkins, Julia E. Janzen, Annette Bernhard, Felix P. Wilhelm, Karén Brien, Donald C. Huang, Jeff Coe, Brian C. Vadasz, David Mayer, Geert Munoz, Douglas P. Oertel, Wolfgang H. Mov Disord Regular Issue Articles BACKGROUND: Parkinson's disease (PD) patients exhibit deficits in saccade performance, pupil function, and blink rate. Isolated REM (rapid eye movement) Sleep Behavior Disorder (RBD) is a harbinger to PD making them candidates to investigate for early oculomotor abnormalities as PD biomarkers. OBJECTIVES: We tested whether saccade, pupillary, and blink responses in RBD were similar to PD. METHODS: RBD (n = 22), PD (n = 22) patients, and healthy controls (CTRL) (n = 74) were studied with video‐based eye‐tracking. RESULTS: RBD patients did not have significantly different saccadic behavior compared to CTRL, but PD patients differed from CTRL and RBD. Both patient groups had significantly lower blink rates, dampened pupil constriction, and dilation responses compared to CTRL. CONCLUSION: RBD and PD patients had altered pupil and blink behavior compared to CTRL. Because RBD saccade parameters were comparable to CTRL, pupil and blink brain areas may be impacted before saccadic control areas, making them potential prodromal PD biomarkers. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society John Wiley & Sons, Inc. 2021-03-22 2021-07 /pmc/articles/PMC8359943/ /pubmed/33754406 http://dx.doi.org/10.1002/mds.28585 Text en © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Issue Articles
Perkins, Julia E.
Janzen, Annette
Bernhard, Felix P.
Wilhelm, Karén
Brien, Donald C.
Huang, Jeff
Coe, Brian C.
Vadasz, David
Mayer, Geert
Munoz, Douglas P.
Oertel, Wolfgang H.
Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder
title Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder
title_full Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder
title_fullStr Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder
title_full_unstemmed Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder
title_short Saccade, Pupil, and Blink Responses in Rapid Eye Movement Sleep Behavior Disorder
title_sort saccade, pupil, and blink responses in rapid eye movement sleep behavior disorder
topic Regular Issue Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359943/
https://www.ncbi.nlm.nih.gov/pubmed/33754406
http://dx.doi.org/10.1002/mds.28585
work_keys_str_mv AT perkinsjuliae saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder
AT janzenannette saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder
AT bernhardfelixp saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder
AT wilhelmkaren saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder
AT briendonaldc saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder
AT huangjeff saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder
AT coebrianc saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder
AT vadaszdavid saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder
AT mayergeert saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder
AT munozdouglasp saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder
AT oertelwolfgangh saccadepupilandblinkresponsesinrapideyemovementsleepbehaviordisorder