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Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat

Human prolyl‐hydroxylases (PHDs) are hypoxia‐sensing 2‐oxoglutarate (2OG) oxygenases, catalysis by which suppresses the transcription of hypoxia‐inducible factor target genes. PHD inhibition enables the treatment of anaemia/ischaemia‐related disease. The PHD inhibitor Molidustat is approved for the...

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Detalles Bibliográficos
Autores principales:	Figg, William D., McDonough, Michael A., Chowdhury, Rasheduzzaman, Nakashima, Yu, Zhang, Zhihong, Holt‐Martyn, James P., Krajnc, Alen, Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359944/ https://www.ncbi.nlm.nih.gov/pubmed/33792169 http://dx.doi.org/10.1002/cmdc.202100133

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