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Optimization of indocyanine green angiography for colon perfusion during laparoscopic colorectal surgery

AIM: This study aims to evaluate the extrinsic effects of conditional factors affecting quantitative parameters and to establish the optimization of indocyanine green (ICG) angiography using in vitro experiments and a prospective observational study. METHOD: In vitro experiments were performed to ev...

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Autores principales: Ahn, Hong‐min, Son, Gyung Mo, Lee, In Young, Park, Sang‐Ho, Kim, Nam Su, Baek, Kwang‐Ryul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359947/
https://www.ncbi.nlm.nih.gov/pubmed/33894016
http://dx.doi.org/10.1111/codi.15684
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author Ahn, Hong‐min
Son, Gyung Mo
Lee, In Young
Park, Sang‐Ho
Kim, Nam Su
Baek, Kwang‐Ryul
author_facet Ahn, Hong‐min
Son, Gyung Mo
Lee, In Young
Park, Sang‐Ho
Kim, Nam Su
Baek, Kwang‐Ryul
author_sort Ahn, Hong‐min
collection PubMed
description AIM: This study aims to evaluate the extrinsic effects of conditional factors affecting quantitative parameters and to establish the optimization of indocyanine green (ICG) angiography using in vitro experiments and a prospective observational study. METHOD: In vitro experiments were performed to evaluate the correlation between conditional factors such as camera distance, surrounding lighting, fluorescence emission sources and ICG doses. The fluorescence intensity was measured from the ICG‐containing test tube in each condition. In the clinical study, ICG angiography was applied to patients with colorectal cancer (n = 164). The quantitative perfusion parameters were the maximal fluorescence intensity (F (MAX)), slope, T (1/2MAX) and perfusion time ratio (TR). Camera position, distance to colon, fluorescence emission source, surrounding lighting, site of angiography and ICG specific mode were considered as conditional factors and compared with the quantitative parameters to identify the optimal condition of ICG angiography. RESULTS: The fluorescence intensity had an inverse correlation with distance, and the transitional zone was shown at a distance of 4–5 cm by slope differential. F (MAX), T (1/2MAX) and slope were affected significantly by camera distance, site of angiography, fluorescence emission source and ICG mode as conditional factors. On multivariate analysis, F (MAX) was independently associated with spectral ICG mode with red inversion, laser mode and camera distance. Conversely, TR was not related to any conditional factors. CONCLUSION: Since quantitative parameters of ICG angiography are influenced by various conditions, a standardized protocol is required. The application of ICG specific modes with a constant distance of 4–5 cm can provide optimized fluorescence images.
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spelling pubmed-83599472021-08-17 Optimization of indocyanine green angiography for colon perfusion during laparoscopic colorectal surgery Ahn, Hong‐min Son, Gyung Mo Lee, In Young Park, Sang‐Ho Kim, Nam Su Baek, Kwang‐Ryul Colorectal Dis Original Articles AIM: This study aims to evaluate the extrinsic effects of conditional factors affecting quantitative parameters and to establish the optimization of indocyanine green (ICG) angiography using in vitro experiments and a prospective observational study. METHOD: In vitro experiments were performed to evaluate the correlation between conditional factors such as camera distance, surrounding lighting, fluorescence emission sources and ICG doses. The fluorescence intensity was measured from the ICG‐containing test tube in each condition. In the clinical study, ICG angiography was applied to patients with colorectal cancer (n = 164). The quantitative perfusion parameters were the maximal fluorescence intensity (F (MAX)), slope, T (1/2MAX) and perfusion time ratio (TR). Camera position, distance to colon, fluorescence emission source, surrounding lighting, site of angiography and ICG specific mode were considered as conditional factors and compared with the quantitative parameters to identify the optimal condition of ICG angiography. RESULTS: The fluorescence intensity had an inverse correlation with distance, and the transitional zone was shown at a distance of 4–5 cm by slope differential. F (MAX), T (1/2MAX) and slope were affected significantly by camera distance, site of angiography, fluorescence emission source and ICG mode as conditional factors. On multivariate analysis, F (MAX) was independently associated with spectral ICG mode with red inversion, laser mode and camera distance. Conversely, TR was not related to any conditional factors. CONCLUSION: Since quantitative parameters of ICG angiography are influenced by various conditions, a standardized protocol is required. The application of ICG specific modes with a constant distance of 4–5 cm can provide optimized fluorescence images. John Wiley and Sons Inc. 2021-05-11 2021-07 /pmc/articles/PMC8359947/ /pubmed/33894016 http://dx.doi.org/10.1111/codi.15684 Text en © 2021 The Authors. Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Ahn, Hong‐min
Son, Gyung Mo
Lee, In Young
Park, Sang‐Ho
Kim, Nam Su
Baek, Kwang‐Ryul
Optimization of indocyanine green angiography for colon perfusion during laparoscopic colorectal surgery
title Optimization of indocyanine green angiography for colon perfusion during laparoscopic colorectal surgery
title_full Optimization of indocyanine green angiography for colon perfusion during laparoscopic colorectal surgery
title_fullStr Optimization of indocyanine green angiography for colon perfusion during laparoscopic colorectal surgery
title_full_unstemmed Optimization of indocyanine green angiography for colon perfusion during laparoscopic colorectal surgery
title_short Optimization of indocyanine green angiography for colon perfusion during laparoscopic colorectal surgery
title_sort optimization of indocyanine green angiography for colon perfusion during laparoscopic colorectal surgery
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359947/
https://www.ncbi.nlm.nih.gov/pubmed/33894016
http://dx.doi.org/10.1111/codi.15684
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