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SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia

Beta‐thalassaemia is an inherited blood disorder characterised by ineffective erythropoiesis and anaemia. Consequently, hepcidin expression is reduced resulting in increased iron absorption and primary iron overload. Hepcidin is under the negative control of transmembrane serine protease 6 (TMPRSS6)...

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Detalles Bibliográficos
Autores principales:	Vadolas, Jim, Ng, Garrett Z., Kysenius, Kai, Crouch, Peter J., Dames, Sibylle, Eisermann, Mona, Nualkaew, Tiwaporn, Vilcassim, Shahla, Schaeper, Ute, Grigoriadis, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Haemoglobinopathies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359948/ https://www.ncbi.nlm.nih.gov/pubmed/33942901 http://dx.doi.org/10.1111/bjh.17428

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