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Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5‐fluorouracil toxicity

AIMS: The aim of this study was to identify risk variants and haplotypes that impair dihydropyrimidine dehydrogenase (DPD) activity and are, therefore, candidate risk variants for severe toxicity to 5‐fluorouracil (5‐FU) chemotherapy. METHODS: Plasma dihydrouracil/uracil (UH(2)/U) ratios were measur...

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Detalles Bibliográficos
Autores principales:	Hamzic, Seid, Schärer, Dominic, Offer, Steven M., Meulendijks, Didier, Nakas, Christos, Diasio, Robert B., Fontana, Stefano, Wehrli, Marc, Schürch, Stefan, Amstutz, Ursula, Largiadèr, Carlo R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359980/ https://www.ncbi.nlm.nih.gov/pubmed/33491253 http://dx.doi.org/10.1111/bcp.14742

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