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Cortical Thickness in the Right Anterior Cingulate Cortex Relates to Clinical Response to Left Prefrontal Accelerated Intermittent Theta Burst Stimulation: An Exploratory Study

OBJECTIVES: Accelerated intermittent theta burst stimulation (aiTBS) is a promising treatment option for depressed patients. However, there is a large interindividual variability in clinical effectiveness and individual biomarkers to guide treatment outcome are needed. MATERIALS AND METHODS: Here, t...

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Autores principales: Baeken, Chris, van Beek, Vince, Vanderhasselt, Marie‐Anne, Duprat, Romain, Klooster, Debby
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360012/
https://www.ncbi.nlm.nih.gov/pubmed/33788975
http://dx.doi.org/10.1111/ner.13380
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author Baeken, Chris
van Beek, Vince
Vanderhasselt, Marie‐Anne
Duprat, Romain
Klooster, Debby
author_facet Baeken, Chris
van Beek, Vince
Vanderhasselt, Marie‐Anne
Duprat, Romain
Klooster, Debby
author_sort Baeken, Chris
collection PubMed
description OBJECTIVES: Accelerated intermittent theta burst stimulation (aiTBS) is a promising treatment option for depressed patients. However, there is a large interindividual variability in clinical effectiveness and individual biomarkers to guide treatment outcome are needed. MATERIALS AND METHODS: Here, the relation between cortical thickness and clinical response (17‐item Hamilton Depression Rating Scale) was studied using anatomical MRI data of 50 depressed patients who were included in a randomized, sham‐controlled, double‐blinded, cross‐over aiTBS design (NCT01832805). RESULTS: Baseline cortical thickness in the right caudal part of the anterior cingulate cortex (cACC) was significantly correlated with direct clinical responses in the subgroup who received active aiTBS during the first stimulation week. No correlations were found between baseline cortical thickness and delayed clinical effectiveness. In this particular region, longitudinal changes in cortical thickness were significantly correlated with clinical effectiveness. Furthermore, direct changes in cortical thickness in the right cACC showed predictive potential of delayed clinical responses. CONCLUSION: Cortical thickness within the right cACC might be an important biomarker to predict clinical responses to aiTBS. Additional studies are warranted to substantiate the specific biomarker potential of these parts of the ACC.
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spelling pubmed-83600122021-08-17 Cortical Thickness in the Right Anterior Cingulate Cortex Relates to Clinical Response to Left Prefrontal Accelerated Intermittent Theta Burst Stimulation: An Exploratory Study Baeken, Chris van Beek, Vince Vanderhasselt, Marie‐Anne Duprat, Romain Klooster, Debby Neuromodulation NON‐INVASIVE BRAIN STIMULATION OBJECTIVES: Accelerated intermittent theta burst stimulation (aiTBS) is a promising treatment option for depressed patients. However, there is a large interindividual variability in clinical effectiveness and individual biomarkers to guide treatment outcome are needed. MATERIALS AND METHODS: Here, the relation between cortical thickness and clinical response (17‐item Hamilton Depression Rating Scale) was studied using anatomical MRI data of 50 depressed patients who were included in a randomized, sham‐controlled, double‐blinded, cross‐over aiTBS design (NCT01832805). RESULTS: Baseline cortical thickness in the right caudal part of the anterior cingulate cortex (cACC) was significantly correlated with direct clinical responses in the subgroup who received active aiTBS during the first stimulation week. No correlations were found between baseline cortical thickness and delayed clinical effectiveness. In this particular region, longitudinal changes in cortical thickness were significantly correlated with clinical effectiveness. Furthermore, direct changes in cortical thickness in the right cACC showed predictive potential of delayed clinical responses. CONCLUSION: Cortical thickness within the right cACC might be an important biomarker to predict clinical responses to aiTBS. Additional studies are warranted to substantiate the specific biomarker potential of these parts of the ACC. John Wiley & Sons, Inc. 2021-03-31 2021-07 /pmc/articles/PMC8360012/ /pubmed/33788975 http://dx.doi.org/10.1111/ner.13380 Text en © 2021 The Authors. Neuromodulation: Technology at the Neural Interface published by Wiley Periodicals LLC on behalf of International Neuromodulation Society. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle NON‐INVASIVE BRAIN STIMULATION
Baeken, Chris
van Beek, Vince
Vanderhasselt, Marie‐Anne
Duprat, Romain
Klooster, Debby
Cortical Thickness in the Right Anterior Cingulate Cortex Relates to Clinical Response to Left Prefrontal Accelerated Intermittent Theta Burst Stimulation: An Exploratory Study
title Cortical Thickness in the Right Anterior Cingulate Cortex Relates to Clinical Response to Left Prefrontal Accelerated Intermittent Theta Burst Stimulation: An Exploratory Study
title_full Cortical Thickness in the Right Anterior Cingulate Cortex Relates to Clinical Response to Left Prefrontal Accelerated Intermittent Theta Burst Stimulation: An Exploratory Study
title_fullStr Cortical Thickness in the Right Anterior Cingulate Cortex Relates to Clinical Response to Left Prefrontal Accelerated Intermittent Theta Burst Stimulation: An Exploratory Study
title_full_unstemmed Cortical Thickness in the Right Anterior Cingulate Cortex Relates to Clinical Response to Left Prefrontal Accelerated Intermittent Theta Burst Stimulation: An Exploratory Study
title_short Cortical Thickness in the Right Anterior Cingulate Cortex Relates to Clinical Response to Left Prefrontal Accelerated Intermittent Theta Burst Stimulation: An Exploratory Study
title_sort cortical thickness in the right anterior cingulate cortex relates to clinical response to left prefrontal accelerated intermittent theta burst stimulation: an exploratory study
topic NON‐INVASIVE BRAIN STIMULATION
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360012/
https://www.ncbi.nlm.nih.gov/pubmed/33788975
http://dx.doi.org/10.1111/ner.13380
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