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Development of an antiseizure drug screening platform for Dravet syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program
OBJECTIVE: Dravet syndrome (DS) is a rare but catastrophic genetic epilepsy, with 80% of patients carrying a mutation in the SCN1A gene. Currently, no antiseizure drug (ASD) exists that adequately controls seizures. In the clinic, individuals with DS often present first with a febrile seizure and, s...
Autores principales: | Pernici, Chelsea D., Mensah, Jeffrey A., Dahle, E. Jill, Johnson, Kristina J., Handy, Laura, Buxton, Lauren, Smith, Misty D., West, Peter J., Metcalf, Cameron S., Wilcox, Karen S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360068/ https://www.ncbi.nlm.nih.gov/pubmed/34002394 http://dx.doi.org/10.1111/epi.16925 |
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