Gain‐of‐Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin‐Deficient Diabetes

High fracture rate and high circulating levels of the Wnt inhibitor, sclerostin, have been reported in diabetic patients. We studied the effects of Wnt signaling activation on bone health in a mouse model of insulin‐deficient diabetes. We introduced the sclerostin‐resistant Lrp5 (A214V) mutation, as...

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Detalles Bibliográficos
Autores principales: Leanza, Giulia, Fontana, Francesca, Lee, Seung‐Yon, Remedi, Maria S., Schott, Céline, Ferron, Mathieu, Hamilton‐Hall, Malcolm, Alippe, Yael, Strollo, Rocky, Napoli, Nicola, Civitelli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360087/
https://www.ncbi.nlm.nih.gov/pubmed/33831261
http://dx.doi.org/10.1002/jbmr.4303

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