Methotrexate‐associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: A case report

WHAT IS KNOWN AND OBJECTIVE: Methotrexate‐associated lymphoproliferative disorder (MTX‐LPD) is a rare complication that develops in patients treated with methotrexate (MTX). CASE SUMMARY: A 76‐year‐old male patient had been taking MTX for his rheumatoid arthritis. Computed tomography (CT) revealed m...

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Autores principales: Hirata, Chihiro, Kenzaka, Tsuneaki, Akita, Hozuka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360114/
https://www.ncbi.nlm.nih.gov/pubmed/33768586
http://dx.doi.org/10.1111/jcpt.13415
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author Hirata, Chihiro
Kenzaka, Tsuneaki
Akita, Hozuka
author_facet Hirata, Chihiro
Kenzaka, Tsuneaki
Akita, Hozuka
author_sort Hirata, Chihiro
collection PubMed
description WHAT IS KNOWN AND OBJECTIVE: Methotrexate‐associated lymphoproliferative disorder (MTX‐LPD) is a rare complication that develops in patients treated with methotrexate (MTX). CASE SUMMARY: A 76‐year‐old male patient had been taking MTX for his rheumatoid arthritis. Computed tomography (CT) revealed masses in the liver, right adrenal gland and T6‐T7 vertebra, including an osteolytic lesion. FDG‐PET scan showed increased uptake in each lesion. MTX was discontinued, and CT showed complete remission of the tumours after three months. The disease course confirmed MTX‐LPD diagnosis. WHAT IS NEW AND CONCLUSION: Bone lesions in LPDs mimic those of metastatic cancer. MTX‐LPD should be considered in patients on MTX presenting with mass lesions.
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spelling pubmed-83601142021-08-17 Methotrexate‐associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: A case report Hirata, Chihiro Kenzaka, Tsuneaki Akita, Hozuka J Clin Pharm Ther Case Reports WHAT IS KNOWN AND OBJECTIVE: Methotrexate‐associated lymphoproliferative disorder (MTX‐LPD) is a rare complication that develops in patients treated with methotrexate (MTX). CASE SUMMARY: A 76‐year‐old male patient had been taking MTX for his rheumatoid arthritis. Computed tomography (CT) revealed masses in the liver, right adrenal gland and T6‐T7 vertebra, including an osteolytic lesion. FDG‐PET scan showed increased uptake in each lesion. MTX was discontinued, and CT showed complete remission of the tumours after three months. The disease course confirmed MTX‐LPD diagnosis. WHAT IS NEW AND CONCLUSION: Bone lesions in LPDs mimic those of metastatic cancer. MTX‐LPD should be considered in patients on MTX presenting with mass lesions. John Wiley and Sons Inc. 2021-03-25 2021-08 /pmc/articles/PMC8360114/ /pubmed/33768586 http://dx.doi.org/10.1111/jcpt.13415 Text en © 2021 The Authors. Journal of Clinical Pharmacy and Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Hirata, Chihiro
Kenzaka, Tsuneaki
Akita, Hozuka
Methotrexate‐associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: A case report
title Methotrexate‐associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: A case report
title_full Methotrexate‐associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: A case report
title_fullStr Methotrexate‐associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: A case report
title_full_unstemmed Methotrexate‐associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: A case report
title_short Methotrexate‐associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: A case report
title_sort methotrexate‐associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360114/
https://www.ncbi.nlm.nih.gov/pubmed/33768586
http://dx.doi.org/10.1111/jcpt.13415
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AT kenzakatsuneaki methotrexateassociatedlymphoproliferativedisorderwithanosteolyticvertebrallesioninanelderlypatientwithrheumatoidarthritisacasereport
AT akitahozuka methotrexateassociatedlymphoproliferativedisorderwithanosteolyticvertebrallesioninanelderlypatientwithrheumatoidarthritisacasereport

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