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A Novel HR‐pQCT Image Registration Approach Reveals Sex‐Specific Changes in Cortical Bone Retraction With Aging

During aging, changes in endosteal and periosteal boundaries of cortical bone occur that differ between men and women. We here develop a new procedure that uses high‐resolution peripheral quantitative CT (HR‐pQCT) imaging and 3D registration to identify such changes within the timescale of longitudi...

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Autores principales: van Rietbergen, Bert, Biver, Emmanuel, Chevalley, Thierry, Ito, Keita, Chapurlat, Roland, Ferrari, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360120/
https://www.ncbi.nlm.nih.gov/pubmed/33724532
http://dx.doi.org/10.1002/jbmr.4285
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author van Rietbergen, Bert
Biver, Emmanuel
Chevalley, Thierry
Ito, Keita
Chapurlat, Roland
Ferrari, Serge
author_facet van Rietbergen, Bert
Biver, Emmanuel
Chevalley, Thierry
Ito, Keita
Chapurlat, Roland
Ferrari, Serge
author_sort van Rietbergen, Bert
collection PubMed
description During aging, changes in endosteal and periosteal boundaries of cortical bone occur that differ between men and women. We here develop a new procedure that uses high‐resolution peripheral quantitative CT (HR‐pQCT) imaging and 3D registration to identify such changes within the timescale of longitudinal studies. A first goal was to test the sensitivity of the approach. A second goal was to assess differences in periosteal/endosteal expansion over time between men and women. Rigid 3D registration was used to transform baseline and all follow‐up (FU) images to a common reference configuration for which the region consisting of complete slices (largest common height) was determined. Periosteal and endosteal contours were transformed to the reference position to determine the net periosteal and endosteal expansion distances. To test the sensitivity, images from a short‐term reproducibility study were used (15 female, aged 21 to 47 years, scanned three times). To test differences between men and women, images from a subset of the Geneva Retirees Cohort were used (248 female, 61 male, average age 65 years, 3.5 and 7 years FU). The sensitivity study indicated a least significant change for detecting periosteal/endosteal expansion of 41/31 microns for the radius and 17/26 microns for the tibia. Results of the cohort study showed significant net endosteal retraction only in females at the radius and tibia after 3.5 years (38.0 and 38.4 microns, respectively) that further increased at 7 years FU (70.4 and 70.8 microns, respectively). No significant net periosteal changes were found for males or females at 7 years. The results demonstrate that it is possible to measure changes in endosteal contours in longitudinal studies within several years. For the investigated cohort, significant endosteal retraction was found in females but not in males. Whether these changes in cortical geometry are related to fracture risk remains to be investigated in larger cohorts © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
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spelling pubmed-83601202021-08-17 A Novel HR‐pQCT Image Registration Approach Reveals Sex‐Specific Changes in Cortical Bone Retraction With Aging van Rietbergen, Bert Biver, Emmanuel Chevalley, Thierry Ito, Keita Chapurlat, Roland Ferrari, Serge J Bone Miner Res Original Articles During aging, changes in endosteal and periosteal boundaries of cortical bone occur that differ between men and women. We here develop a new procedure that uses high‐resolution peripheral quantitative CT (HR‐pQCT) imaging and 3D registration to identify such changes within the timescale of longitudinal studies. A first goal was to test the sensitivity of the approach. A second goal was to assess differences in periosteal/endosteal expansion over time between men and women. Rigid 3D registration was used to transform baseline and all follow‐up (FU) images to a common reference configuration for which the region consisting of complete slices (largest common height) was determined. Periosteal and endosteal contours were transformed to the reference position to determine the net periosteal and endosteal expansion distances. To test the sensitivity, images from a short‐term reproducibility study were used (15 female, aged 21 to 47 years, scanned three times). To test differences between men and women, images from a subset of the Geneva Retirees Cohort were used (248 female, 61 male, average age 65 years, 3.5 and 7 years FU). The sensitivity study indicated a least significant change for detecting periosteal/endosteal expansion of 41/31 microns for the radius and 17/26 microns for the tibia. Results of the cohort study showed significant net endosteal retraction only in females at the radius and tibia after 3.5 years (38.0 and 38.4 microns, respectively) that further increased at 7 years FU (70.4 and 70.8 microns, respectively). No significant net periosteal changes were found for males or females at 7 years. The results demonstrate that it is possible to measure changes in endosteal contours in longitudinal studies within several years. For the investigated cohort, significant endosteal retraction was found in females but not in males. Whether these changes in cortical geometry are related to fracture risk remains to be investigated in larger cohorts © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). John Wiley & Sons, Inc. 2021-03-30 2021-07 /pmc/articles/PMC8360120/ /pubmed/33724532 http://dx.doi.org/10.1002/jbmr.4285 Text en © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
van Rietbergen, Bert
Biver, Emmanuel
Chevalley, Thierry
Ito, Keita
Chapurlat, Roland
Ferrari, Serge
A Novel HR‐pQCT Image Registration Approach Reveals Sex‐Specific Changes in Cortical Bone Retraction With Aging
title A Novel HR‐pQCT Image Registration Approach Reveals Sex‐Specific Changes in Cortical Bone Retraction With Aging
title_full A Novel HR‐pQCT Image Registration Approach Reveals Sex‐Specific Changes in Cortical Bone Retraction With Aging
title_fullStr A Novel HR‐pQCT Image Registration Approach Reveals Sex‐Specific Changes in Cortical Bone Retraction With Aging
title_full_unstemmed A Novel HR‐pQCT Image Registration Approach Reveals Sex‐Specific Changes in Cortical Bone Retraction With Aging
title_short A Novel HR‐pQCT Image Registration Approach Reveals Sex‐Specific Changes in Cortical Bone Retraction With Aging
title_sort novel hr‐pqct image registration approach reveals sex‐specific changes in cortical bone retraction with aging
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360120/
https://www.ncbi.nlm.nih.gov/pubmed/33724532
http://dx.doi.org/10.1002/jbmr.4285
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