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Cryo‐kinetics Reveal Dynamic Effects on the Chemistry of Human Dihydrofolate Reductase

Effects of isotopic substitution on the rate constants of human dihydrofolate reductase (HsDHFR), an important target for anti‐cancer drugs, have not previously been characterized due to its complex fast kinetics. Here, we report the results of cryo‐measurements of the kinetics of the HsDHFR catalyz...

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Detalles Bibliográficos
Autores principales:	Adesina, Aduragbemi S., Luk, Louis Y. P., Allemann, Rudolf K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360168/ https://www.ncbi.nlm.nih.gov/pubmed/33876533 http://dx.doi.org/10.1002/cbic.202100017

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