Cargando…

Perceived psychological stress and risk of herpes zoster: a nationwide population‐based cohort study

BACKGROUND: Psychological stress may reduce cellular immunity, but its role in triggering latent infections, including herpes zoster (HZ), is controversial. OBJECTIVES: To examine the association between perceived psychological stress and risk of HZ. METHODS: In a linked registry‐based cohort study,...

Descripción completa

Detalles Bibliográficos
Autores principales: Schmidt, S.A.J., Sørensen, H.T., Langan, S.M., Vestergaard, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360205/
https://www.ncbi.nlm.nih.gov/pubmed/33511645
http://dx.doi.org/10.1111/bjd.19832
_version_ 1783737700800528384
author Schmidt, S.A.J.
Sørensen, H.T.
Langan, S.M.
Vestergaard, M.
author_facet Schmidt, S.A.J.
Sørensen, H.T.
Langan, S.M.
Vestergaard, M.
author_sort Schmidt, S.A.J.
collection PubMed
description BACKGROUND: Psychological stress may reduce cellular immunity, but its role in triggering latent infections, including herpes zoster (HZ), is controversial. OBJECTIVES: To examine the association between perceived psychological stress and risk of HZ. METHODS: In a linked registry‐based cohort study, we followed 77 310 persons aged 40 years or older who participated in the 2010 Danish National Health Survey from 1 May 2010 until HZ diagnosis, death, emigration or 1 July 2014, whichever occurred first. We computed hazard ratios (HRs) of HZ associated with Cohen’s Perceived Stress Scale (PSS) score (range 0–40) using Cox regression with age as the timescale, adjusted for sex, immunosuppressive and selected chronic conditions, immunosuppressive drugs, and sociodemographic, lifestyle and anthropometric factors. The PSS measures chronic stress perceived by an individual in response to various demands of daily life. We modelled the PSS score using quintiles and a restricted cubic spline function. RESULTS: The unadjusted rate of HZ varied from 5·53 to 7·20 per 1000 person‐years from the lowest to the highest PSS score quintile. Compared with the lowest PSS score quintile, the adjusted HR for HZ was 1·00 [95% confidence interval (CI) 0·86–1·16], 1·08 (95% CI 0·92–1·26), 1·05 (95% CI 0·90–1·23) and 1·14 (95% CI 0·97–1·34) for the second to the fifth quintile, respectively. In cubic spline analyses, PSS scores < 20 were not associated with increased HR of HZ, but thereafter the HR increased linearly from 1·10 (95% CI 0·85–1·41) to 2·22 (95% CI 1·32–3·75). CONCLUSIONS: Our study indicated that high levels of psychological stress are associated with increased risk of HZ.
format Online
Article
Text
id pubmed-8360205
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-83602052021-08-17 Perceived psychological stress and risk of herpes zoster: a nationwide population‐based cohort study Schmidt, S.A.J. Sørensen, H.T. Langan, S.M. Vestergaard, M. Br J Dermatol Original Articles BACKGROUND: Psychological stress may reduce cellular immunity, but its role in triggering latent infections, including herpes zoster (HZ), is controversial. OBJECTIVES: To examine the association between perceived psychological stress and risk of HZ. METHODS: In a linked registry‐based cohort study, we followed 77 310 persons aged 40 years or older who participated in the 2010 Danish National Health Survey from 1 May 2010 until HZ diagnosis, death, emigration or 1 July 2014, whichever occurred first. We computed hazard ratios (HRs) of HZ associated with Cohen’s Perceived Stress Scale (PSS) score (range 0–40) using Cox regression with age as the timescale, adjusted for sex, immunosuppressive and selected chronic conditions, immunosuppressive drugs, and sociodemographic, lifestyle and anthropometric factors. The PSS measures chronic stress perceived by an individual in response to various demands of daily life. We modelled the PSS score using quintiles and a restricted cubic spline function. RESULTS: The unadjusted rate of HZ varied from 5·53 to 7·20 per 1000 person‐years from the lowest to the highest PSS score quintile. Compared with the lowest PSS score quintile, the adjusted HR for HZ was 1·00 [95% confidence interval (CI) 0·86–1·16], 1·08 (95% CI 0·92–1·26), 1·05 (95% CI 0·90–1·23) and 1·14 (95% CI 0·97–1·34) for the second to the fifth quintile, respectively. In cubic spline analyses, PSS scores < 20 were not associated with increased HR of HZ, but thereafter the HR increased linearly from 1·10 (95% CI 0·85–1·41) to 2·22 (95% CI 1·32–3·75). CONCLUSIONS: Our study indicated that high levels of psychological stress are associated with increased risk of HZ. John Wiley and Sons Inc. 2021-05-07 2021-07 /pmc/articles/PMC8360205/ /pubmed/33511645 http://dx.doi.org/10.1111/bjd.19832 Text en © 2021 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Schmidt, S.A.J.
Sørensen, H.T.
Langan, S.M.
Vestergaard, M.
Perceived psychological stress and risk of herpes zoster: a nationwide population‐based cohort study
title Perceived psychological stress and risk of herpes zoster: a nationwide population‐based cohort study
title_full Perceived psychological stress and risk of herpes zoster: a nationwide population‐based cohort study
title_fullStr Perceived psychological stress and risk of herpes zoster: a nationwide population‐based cohort study
title_full_unstemmed Perceived psychological stress and risk of herpes zoster: a nationwide population‐based cohort study
title_short Perceived psychological stress and risk of herpes zoster: a nationwide population‐based cohort study
title_sort perceived psychological stress and risk of herpes zoster: a nationwide population‐based cohort study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360205/
https://www.ncbi.nlm.nih.gov/pubmed/33511645
http://dx.doi.org/10.1111/bjd.19832
work_keys_str_mv AT schmidtsaj perceivedpsychologicalstressandriskofherpeszosteranationwidepopulationbasedcohortstudy
AT sørensenht perceivedpsychologicalstressandriskofherpeszosteranationwidepopulationbasedcohortstudy
AT langansm perceivedpsychologicalstressandriskofherpeszosteranationwidepopulationbasedcohortstudy
AT vestergaardm perceivedpsychologicalstressandriskofherpeszosteranationwidepopulationbasedcohortstudy