Light-Emitting Probes for Labeling Peptides

Peptides are versatile biopolymers composed of 2–100 amino acid residues that present a wide range of biological functions and constitute potential therapies for numerous diseases, partly due to their ability to penetrate cell membranes. However, their mechanisms of action have not been fully elucid...

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Detalles Bibliográficos
Autores principales: Boaro, Andreia, Ageitos, Lucía, Torres, Marcelo, Bartoloni, Fernando Heering, de la Fuente-Nunez, Cesar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360326/
https://www.ncbi.nlm.nih.gov/pubmed/34396352
http://dx.doi.org/10.1016/j.xcrp.2020.100257
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author Boaro, Andreia
Ageitos, Lucía
Torres, Marcelo
Bartoloni, Fernando Heering
de la Fuente-Nunez, Cesar
author_facet Boaro, Andreia
Ageitos, Lucía
Torres, Marcelo
Bartoloni, Fernando Heering
de la Fuente-Nunez, Cesar
author_sort Boaro, Andreia
collection PubMed
description Peptides are versatile biopolymers composed of 2–100 amino acid residues that present a wide range of biological functions and constitute potential therapies for numerous diseases, partly due to their ability to penetrate cell membranes. However, their mechanisms of action have not been fully elucidated due to the lack of appropriate tools. Existing light-emitting probes are limited by their cytotoxicity and large size, which can alter peptide structure and function. Here, we describe the available fluorescent, bioluminescent, and chemiluminescent probes for labeling peptides, with a focus on minimalistic options.
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spelling pubmed-83603262021-08-12 Light-Emitting Probes for Labeling Peptides Boaro, Andreia Ageitos, Lucía Torres, Marcelo Bartoloni, Fernando Heering de la Fuente-Nunez, Cesar Cell Rep Phys Sci Article Peptides are versatile biopolymers composed of 2–100 amino acid residues that present a wide range of biological functions and constitute potential therapies for numerous diseases, partly due to their ability to penetrate cell membranes. However, their mechanisms of action have not been fully elucidated due to the lack of appropriate tools. Existing light-emitting probes are limited by their cytotoxicity and large size, which can alter peptide structure and function. Here, we describe the available fluorescent, bioluminescent, and chemiluminescent probes for labeling peptides, with a focus on minimalistic options. 2020-11-25 2020-12-23 /pmc/articles/PMC8360326/ /pubmed/34396352 http://dx.doi.org/10.1016/j.xcrp.2020.100257 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Boaro, Andreia
Ageitos, Lucía
Torres, Marcelo
Bartoloni, Fernando Heering
de la Fuente-Nunez, Cesar
Light-Emitting Probes for Labeling Peptides
title Light-Emitting Probes for Labeling Peptides
title_full Light-Emitting Probes for Labeling Peptides
title_fullStr Light-Emitting Probes for Labeling Peptides
title_full_unstemmed Light-Emitting Probes for Labeling Peptides
title_short Light-Emitting Probes for Labeling Peptides
title_sort light-emitting probes for labeling peptides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360326/
https://www.ncbi.nlm.nih.gov/pubmed/34396352
http://dx.doi.org/10.1016/j.xcrp.2020.100257
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AT delafuentenunezcesar lightemittingprobesforlabelingpeptides

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