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Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation
BACKGROUND: Plenty of studies have showed matrix metalloproteinase 14 (MMP14) expression might be associated with the prognosis of gastric cancer (GC). However, no definite conclusion has been obtained for the contradictory results. METHODS: We searched PubMed, Web of science, Embase, and Cochrane l...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360427/ https://www.ncbi.nlm.nih.gov/pubmed/34397871 http://dx.doi.org/10.1097/MD.0000000000026545 |
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author | Wang, Xikai Meng, Qinghe Wang, Yuanyuan Gao, Yanlu |
author_facet | Wang, Xikai Meng, Qinghe Wang, Yuanyuan Gao, Yanlu |
author_sort | Wang, Xikai |
collection | PubMed |
description | BACKGROUND: Plenty of studies have showed matrix metalloproteinase 14 (MMP14) expression might be associated with the prognosis of gastric cancer (GC). However, no definite conclusion has been obtained for the contradictory results. METHODS: We searched PubMed, Web of science, Embase, and Cochrane library for eligible studies. The association between MMP14 expression and prognostic outcomes of GC was evaluated. Hazard ratio (HR) and 95% confidence interval (CI) were integrated to show the effect of MMP14 expression on the overall survival (OS) or recurrence-free survival (RFS). Data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) was used to validate the association of MMP14 expression with OS or RFS in GC. A brief bioinformatics analysis was also performed to determine the prognostic role of MMP14 expression in GC. RESULTS: High MMP14 expression was associated with shorter OS compared to low MMP14 expression in GC (HR = 1.95, P < .01). Patients with high MMP14 expression tended to have worse differentiation (P = .03), deeper tumor invasion (P < .01), earlier lymph node metastasis (P < .01), earlier distant metastasis (P < .01) and more advanced clinical stage (P < .01) compared to those with low MMP14 expression. The data from TCGA and GEO showed MMP14 was overexpressed in tumor tissues compared to normal tissues (P < .05), and high MMP14 expression was significantly related to shorter OS (HR = 1.70, 95% CI = 1.32–2.20, P < .01) and RFS (HR = 1.45, 95% CI = 1.15–1.83, P < .01) compared to low MMP14 expression in GC. Expression of MMP14 was linked to functional networks involving the biological process, metabolic process, response to stimulus, cell communication and so on. Functional network analysis suggested that MMP14 regulated the protein digestion and absorption, extracellular matrix receptor interaction, focal adhesion, ribosome, spliceosome, and so on. CONCLUSION: High MMP14 expression was associated with worse prognosis of GC compared to low MMP14 expression. MMP14 expression could serve as a prognostic factor and potential therapeutic target of GC. |
format | Online Article Text |
id | pubmed-8360427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-83604272021-08-14 Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation Wang, Xikai Meng, Qinghe Wang, Yuanyuan Gao, Yanlu Medicine (Baltimore) 5700 BACKGROUND: Plenty of studies have showed matrix metalloproteinase 14 (MMP14) expression might be associated with the prognosis of gastric cancer (GC). However, no definite conclusion has been obtained for the contradictory results. METHODS: We searched PubMed, Web of science, Embase, and Cochrane library for eligible studies. The association between MMP14 expression and prognostic outcomes of GC was evaluated. Hazard ratio (HR) and 95% confidence interval (CI) were integrated to show the effect of MMP14 expression on the overall survival (OS) or recurrence-free survival (RFS). Data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) was used to validate the association of MMP14 expression with OS or RFS in GC. A brief bioinformatics analysis was also performed to determine the prognostic role of MMP14 expression in GC. RESULTS: High MMP14 expression was associated with shorter OS compared to low MMP14 expression in GC (HR = 1.95, P < .01). Patients with high MMP14 expression tended to have worse differentiation (P = .03), deeper tumor invasion (P < .01), earlier lymph node metastasis (P < .01), earlier distant metastasis (P < .01) and more advanced clinical stage (P < .01) compared to those with low MMP14 expression. The data from TCGA and GEO showed MMP14 was overexpressed in tumor tissues compared to normal tissues (P < .05), and high MMP14 expression was significantly related to shorter OS (HR = 1.70, 95% CI = 1.32–2.20, P < .01) and RFS (HR = 1.45, 95% CI = 1.15–1.83, P < .01) compared to low MMP14 expression in GC. Expression of MMP14 was linked to functional networks involving the biological process, metabolic process, response to stimulus, cell communication and so on. Functional network analysis suggested that MMP14 regulated the protein digestion and absorption, extracellular matrix receptor interaction, focal adhesion, ribosome, spliceosome, and so on. CONCLUSION: High MMP14 expression was associated with worse prognosis of GC compared to low MMP14 expression. MMP14 expression could serve as a prognostic factor and potential therapeutic target of GC. Lippincott Williams & Wilkins 2021-08-13 /pmc/articles/PMC8360427/ /pubmed/34397871 http://dx.doi.org/10.1097/MD.0000000000026545 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 5700 Wang, Xikai Meng, Qinghe Wang, Yuanyuan Gao, Yanlu Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation |
title | Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation |
title_full | Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation |
title_fullStr | Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation |
title_full_unstemmed | Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation |
title_short | Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation |
title_sort | overexpression of mmp14 predicts the poor prognosis in gastric cancer: meta-analysis and database validation |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360427/ https://www.ncbi.nlm.nih.gov/pubmed/34397871 http://dx.doi.org/10.1097/MD.0000000000026545 |
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