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A meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma
BACKGROUND: Papillary thyroid carcinoma (PTC) incidence has been increasing worldwide. Obesity, that is, having a high body mass index, is associated with the incidence of several cancers including colon, breast, esophageal, and kidney cancer. However, the association between obesity and the clinica...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360437/ https://www.ncbi.nlm.nih.gov/pubmed/34397906 http://dx.doi.org/10.1097/MD.0000000000026882 |
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author | Cui, Ningning Sun, Qian Chen, Li |
author_facet | Cui, Ningning Sun, Qian Chen, Li |
author_sort | Cui, Ningning |
collection | PubMed |
description | BACKGROUND: Papillary thyroid carcinoma (PTC) incidence has been increasing worldwide. Obesity, that is, having a high body mass index, is associated with the incidence of several cancers including colon, breast, esophageal, and kidney cancer. However, the association between obesity and the clinical features of PTC is still unknown. This study aimed to determine the impact of obesity on the clinical features of PTC. METHOD: A database search was conducted for articles published up to 2020 on obesity and clinical features of PTC. Data were extracted from articles that met the meta-analysis inclusion criteria. RESULTS: A total of 11 retrospective cohorts and 11,729 patients were included. Obesity was associated with the following variables in PTC patients: older age (difference in means = 1.95, 95% confidence interval [CI] 0.16–3.74, P = .03), male sex (odds ratio [OR] = 3.13, 95%CI 2.24–4.38, P < .00001), tumor size ≥1 cm (OR = 1.34, 95%CI 1.11–1.61, P < .002), multifocality (OR = 1.54, 95%CI 1.27–1.88, P < .0001), extrathyroidal extension (OR = 1.78, 95%CI 1.22–2.59, P = .003) and advanced tumor, node, metastasis stage (OR = 1.68, 95%CI 1.44–1.96, P < .00001). Preoperative serum thyroid-stimulating hormone level (difference in means = 0.09, 95%CI 0.35–0.52, P = .70), Vascular invasion (OR = 0.84, 95%CI 0.56–1.26, P = .41), lymph node metastasis (OR = 1.07, 95%CI 0.87–1.32, P = .50), distant metastasis (OR = 1.14, 95%CI 0.64–2.04, P = .66), and recurrence (OR = 1.45, 95%CI 0.97–2.15, P = .07) were not associated with obesity. CONCLUSION: Obesity was associated with several poor clinicopathologic prognostic features: older age, male gender, tumor size ≥1 cm, extrathyroidal extension, multifocality, and advanced tumor/node/metastasis stage. However, thyroid-stimulating hormone level, vascular invasion, lymph node metastasis, distant metastasis, and recurrence were not associated with obesity in PTC. |
format | Online Article Text |
id | pubmed-8360437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-83604372021-08-14 A meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma Cui, Ningning Sun, Qian Chen, Li Medicine (Baltimore) 4300 BACKGROUND: Papillary thyroid carcinoma (PTC) incidence has been increasing worldwide. Obesity, that is, having a high body mass index, is associated with the incidence of several cancers including colon, breast, esophageal, and kidney cancer. However, the association between obesity and the clinical features of PTC is still unknown. This study aimed to determine the impact of obesity on the clinical features of PTC. METHOD: A database search was conducted for articles published up to 2020 on obesity and clinical features of PTC. Data were extracted from articles that met the meta-analysis inclusion criteria. RESULTS: A total of 11 retrospective cohorts and 11,729 patients were included. Obesity was associated with the following variables in PTC patients: older age (difference in means = 1.95, 95% confidence interval [CI] 0.16–3.74, P = .03), male sex (odds ratio [OR] = 3.13, 95%CI 2.24–4.38, P < .00001), tumor size ≥1 cm (OR = 1.34, 95%CI 1.11–1.61, P < .002), multifocality (OR = 1.54, 95%CI 1.27–1.88, P < .0001), extrathyroidal extension (OR = 1.78, 95%CI 1.22–2.59, P = .003) and advanced tumor, node, metastasis stage (OR = 1.68, 95%CI 1.44–1.96, P < .00001). Preoperative serum thyroid-stimulating hormone level (difference in means = 0.09, 95%CI 0.35–0.52, P = .70), Vascular invasion (OR = 0.84, 95%CI 0.56–1.26, P = .41), lymph node metastasis (OR = 1.07, 95%CI 0.87–1.32, P = .50), distant metastasis (OR = 1.14, 95%CI 0.64–2.04, P = .66), and recurrence (OR = 1.45, 95%CI 0.97–2.15, P = .07) were not associated with obesity. CONCLUSION: Obesity was associated with several poor clinicopathologic prognostic features: older age, male gender, tumor size ≥1 cm, extrathyroidal extension, multifocality, and advanced tumor/node/metastasis stage. However, thyroid-stimulating hormone level, vascular invasion, lymph node metastasis, distant metastasis, and recurrence were not associated with obesity in PTC. Lippincott Williams & Wilkins 2021-08-13 /pmc/articles/PMC8360437/ /pubmed/34397906 http://dx.doi.org/10.1097/MD.0000000000026882 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 4300 Cui, Ningning Sun, Qian Chen, Li A meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma |
title | A meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma |
title_full | A meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma |
title_fullStr | A meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma |
title_full_unstemmed | A meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma |
title_short | A meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma |
title_sort | meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma |
topic | 4300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360437/ https://www.ncbi.nlm.nih.gov/pubmed/34397906 http://dx.doi.org/10.1097/MD.0000000000026882 |
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