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The association between overweight and obesity on bone mineral density in 12 to 15 years old adolescents in China

Overweight/obesity can influence bone mineral accretion, but the conclusions are not consistent. We aimed to examine the association between bone mineral density (BMD) levels and body mass index (BMI) in 12 to 15 years old adolescents. We performed a cross-sectional study including 8365 adolescents....

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Autores principales: Wang, Leishen, Xu, Zhongxian, Li, Nan, Meng, Xuemei, Wang, Shuo, Yu, Chengshu, Leng, Junhong, Zhao, Ming, Li, Weiqin, Deng, Yanmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360441/
https://www.ncbi.nlm.nih.gov/pubmed/34397903
http://dx.doi.org/10.1097/MD.0000000000026872
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author Wang, Leishen
Xu, Zhongxian
Li, Nan
Meng, Xuemei
Wang, Shuo
Yu, Chengshu
Leng, Junhong
Zhao, Ming
Li, Weiqin
Deng, Yanmei
author_facet Wang, Leishen
Xu, Zhongxian
Li, Nan
Meng, Xuemei
Wang, Shuo
Yu, Chengshu
Leng, Junhong
Zhao, Ming
Li, Weiqin
Deng, Yanmei
author_sort Wang, Leishen
collection PubMed
description Overweight/obesity can influence bone mineral accretion, but the conclusions are not consistent. We aimed to examine the association between bone mineral density (BMD) levels and body mass index (BMI) in 12 to 15 years old adolescents. We performed a cross-sectional study including 8365 adolescents. BMD was evaluated using a quantitative ultrasound device. Z scores for BMI were evaluated using World Health Organization references. Logistic regression models were performed to evaluate the association between BMD levels and BMI. Totally 1866 (22.3%) adolescents had low /reduced BMD, and boys had a higher rate than girls (72.6% vs 27.4%, P < .001). The rates of thinness, normal weight, overweight, and obesity were 2.8%, 57.1%, 22.3%, and 17.8%, respectively. The multivariable-adjusted (age, sex, systolic blood pressure, and height Z score) ORs (95% CIs) of low/reduced BMD associated with BMI groups (thinness, normal [reference], overweight, and obesity) were 0.59 (0.39–0.89), 1.00, 1.61 (1.41–1.84), and 1.98 (1.69–2.30), respectively (P(trend) < .001). This positive association existed in boys and girls though the differences were not significant between normal weight and thin girls. The multivariable-adjusted ORs for each 1-unit increase in BMI Z score were 1.36 (1.24–1.49) for girls, and 1.23 (1.16–1.30) for boys, and 1.26 (1.20–1.32) for all participants. We observed a positive association between BMI and low/reduced BMD in 12 to 15 years old adolescents. More attention should be paid on overweight and obese adolescents to reduce the risk of low BMD. Further studies are needed to explore the mechanisms of this association.
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spelling pubmed-83604412021-08-14 The association between overweight and obesity on bone mineral density in 12 to 15 years old adolescents in China Wang, Leishen Xu, Zhongxian Li, Nan Meng, Xuemei Wang, Shuo Yu, Chengshu Leng, Junhong Zhao, Ming Li, Weiqin Deng, Yanmei Medicine (Baltimore) 6200 Overweight/obesity can influence bone mineral accretion, but the conclusions are not consistent. We aimed to examine the association between bone mineral density (BMD) levels and body mass index (BMI) in 12 to 15 years old adolescents. We performed a cross-sectional study including 8365 adolescents. BMD was evaluated using a quantitative ultrasound device. Z scores for BMI were evaluated using World Health Organization references. Logistic regression models were performed to evaluate the association between BMD levels and BMI. Totally 1866 (22.3%) adolescents had low /reduced BMD, and boys had a higher rate than girls (72.6% vs 27.4%, P < .001). The rates of thinness, normal weight, overweight, and obesity were 2.8%, 57.1%, 22.3%, and 17.8%, respectively. The multivariable-adjusted (age, sex, systolic blood pressure, and height Z score) ORs (95% CIs) of low/reduced BMD associated with BMI groups (thinness, normal [reference], overweight, and obesity) were 0.59 (0.39–0.89), 1.00, 1.61 (1.41–1.84), and 1.98 (1.69–2.30), respectively (P(trend) < .001). This positive association existed in boys and girls though the differences were not significant between normal weight and thin girls. The multivariable-adjusted ORs for each 1-unit increase in BMI Z score were 1.36 (1.24–1.49) for girls, and 1.23 (1.16–1.30) for boys, and 1.26 (1.20–1.32) for all participants. We observed a positive association between BMI and low/reduced BMD in 12 to 15 years old adolescents. More attention should be paid on overweight and obese adolescents to reduce the risk of low BMD. Further studies are needed to explore the mechanisms of this association. Lippincott Williams & Wilkins 2021-08-13 /pmc/articles/PMC8360441/ /pubmed/34397903 http://dx.doi.org/10.1097/MD.0000000000026872 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 6200
Wang, Leishen
Xu, Zhongxian
Li, Nan
Meng, Xuemei
Wang, Shuo
Yu, Chengshu
Leng, Junhong
Zhao, Ming
Li, Weiqin
Deng, Yanmei
The association between overweight and obesity on bone mineral density in 12 to 15 years old adolescents in China
title The association between overweight and obesity on bone mineral density in 12 to 15 years old adolescents in China
title_full The association between overweight and obesity on bone mineral density in 12 to 15 years old adolescents in China
title_fullStr The association between overweight and obesity on bone mineral density in 12 to 15 years old adolescents in China
title_full_unstemmed The association between overweight and obesity on bone mineral density in 12 to 15 years old adolescents in China
title_short The association between overweight and obesity on bone mineral density in 12 to 15 years old adolescents in China
title_sort association between overweight and obesity on bone mineral density in 12 to 15 years old adolescents in china
topic 6200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360441/
https://www.ncbi.nlm.nih.gov/pubmed/34397903
http://dx.doi.org/10.1097/MD.0000000000026872
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