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Association between CYP2B6 c.516G >T variant and acute leukaemia: A protocol for systematic review and meta-analysis
BACKGROUND: Acute leukemia (AL) is a kind of malignant tumor of hematopoietic system. A number of studies have suggested that Single Nucleotide Polymorphisms are significantly associated with risk of AL. Present study performs meta-analysis to evaluate the association between CYP2B6 c.516G>T vari...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360481/ https://www.ncbi.nlm.nih.gov/pubmed/34397877 http://dx.doi.org/10.1097/MD.0000000000026740 |
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author | Xiong, Xuan Yu, Dongke Gao, Qiaoyue Zhang, Yuan Yin, Qinan Chen, Xiaotao Xiao, Hongtao Tong, Rongsheng |
author_facet | Xiong, Xuan Yu, Dongke Gao, Qiaoyue Zhang, Yuan Yin, Qinan Chen, Xiaotao Xiao, Hongtao Tong, Rongsheng |
author_sort | Xiong, Xuan |
collection | PubMed |
description | BACKGROUND: Acute leukemia (AL) is a kind of malignant tumor of hematopoietic system. A number of studies have suggested that Single Nucleotide Polymorphisms are significantly associated with risk of AL. Present study performs meta-analysis to evaluate the association between CYP2B6 c.516G>T variant and AL risk. METHODS: Databases including PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang were searched for literatures to September 30, 2019, both in English and Chinese. Relative risk and its 95% confidence intervals were used to assess the associations. Statistical analyses of this meta-analysis were conducted by using STATA 13.0. software. RESULTS: A total of 7 studies, including 1038 cases and 1648 controls, were analyzed. Our results indicated that CYP2B6 c.516G>T variant was significantly related to an increased the risk of AL under dominant model, recessive model, homozygote model, and allelic model. In addition, subgroup analyses were also performed by disease classification, country, and study design. No significant associations were obtained between CYP2B6 c.516G>T variant and the risk of AL under the recessive model in the design of hospital-based (relative risk = 0.98; 95% confidence interval: 0.95–1.01; P = 0.118). CONCLUSION: Our meta-analysis indicated that the CYP2B6 variant is significantly associated with AL risk, in which CYP2B6 c.516G>T is related to an increased risk of AL. |
format | Online Article Text |
id | pubmed-8360481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-83604812021-08-17 Association between CYP2B6 c.516G >T variant and acute leukaemia: A protocol for systematic review and meta-analysis Xiong, Xuan Yu, Dongke Gao, Qiaoyue Zhang, Yuan Yin, Qinan Chen, Xiaotao Xiao, Hongtao Tong, Rongsheng Medicine (Baltimore) 3500 BACKGROUND: Acute leukemia (AL) is a kind of malignant tumor of hematopoietic system. A number of studies have suggested that Single Nucleotide Polymorphisms are significantly associated with risk of AL. Present study performs meta-analysis to evaluate the association between CYP2B6 c.516G>T variant and AL risk. METHODS: Databases including PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang were searched for literatures to September 30, 2019, both in English and Chinese. Relative risk and its 95% confidence intervals were used to assess the associations. Statistical analyses of this meta-analysis were conducted by using STATA 13.0. software. RESULTS: A total of 7 studies, including 1038 cases and 1648 controls, were analyzed. Our results indicated that CYP2B6 c.516G>T variant was significantly related to an increased the risk of AL under dominant model, recessive model, homozygote model, and allelic model. In addition, subgroup analyses were also performed by disease classification, country, and study design. No significant associations were obtained between CYP2B6 c.516G>T variant and the risk of AL under the recessive model in the design of hospital-based (relative risk = 0.98; 95% confidence interval: 0.95–1.01; P = 0.118). CONCLUSION: Our meta-analysis indicated that the CYP2B6 variant is significantly associated with AL risk, in which CYP2B6 c.516G>T is related to an increased risk of AL. Lippincott Williams & Wilkins 2021-08-13 /pmc/articles/PMC8360481/ /pubmed/34397877 http://dx.doi.org/10.1097/MD.0000000000026740 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 3500 Xiong, Xuan Yu, Dongke Gao, Qiaoyue Zhang, Yuan Yin, Qinan Chen, Xiaotao Xiao, Hongtao Tong, Rongsheng Association between CYP2B6 c.516G >T variant and acute leukaemia: A protocol for systematic review and meta-analysis |
title | Association between CYP2B6 c.516G >T variant and acute leukaemia: A protocol for systematic review and meta-analysis |
title_full | Association between CYP2B6 c.516G >T variant and acute leukaemia: A protocol for systematic review and meta-analysis |
title_fullStr | Association between CYP2B6 c.516G >T variant and acute leukaemia: A protocol for systematic review and meta-analysis |
title_full_unstemmed | Association between CYP2B6 c.516G >T variant and acute leukaemia: A protocol for systematic review and meta-analysis |
title_short | Association between CYP2B6 c.516G >T variant and acute leukaemia: A protocol for systematic review and meta-analysis |
title_sort | association between cyp2b6 c.516g >t variant and acute leukaemia: a protocol for systematic review and meta-analysis |
topic | 3500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360481/ https://www.ncbi.nlm.nih.gov/pubmed/34397877 http://dx.doi.org/10.1097/MD.0000000000026740 |
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