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High-resolution, genome-wide mapping of positive supercoiling in chromosomes

Supercoiling impacts DNA replication, transcription, protein binding to DNA, and the three-dimensional organization of chromosomes. However, there are currently no methods to directly interrogate or map positive supercoils, so their distribution in genomes remains unknown. Here, we describe a method...

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Detalles Bibliográficos
Autores principales:	Guo, Monica S, Kawamura, Ryo, Littlehale, Megan L, Marko, John F, Laub, Michael T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360656/ https://www.ncbi.nlm.nih.gov/pubmed/34279217 http://dx.doi.org/10.7554/eLife.67236

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