Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma With a BRAF Mutation: A Case Report

A 44-yr-old woman presented with lower, painless abdominal discomfort and a vacuolated mass measuring 12 cm on the right-hand side of the pelvis. She subsequently underwent a bilateral salpingo-oophorectomy. An osseous lesion was identified in the left ovary, which was hard in consistency and was as...

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Autores principales: Catteau, Xavier, Preat, Fanny, D’haene, Nicky, Noël, Jean-Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Pathology of the Upper Tract: Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360659/
https://www.ncbi.nlm.nih.gov/pubmed/33252399
http://dx.doi.org/10.1097/PGP.0000000000000732
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author Catteau, Xavier
Preat, Fanny
D’haene, Nicky
Noël, Jean-Christophe
author_facet Catteau, Xavier
Preat, Fanny
D’haene, Nicky
Noël, Jean-Christophe
author_sort Catteau, Xavier
collection PubMed
description A 44-yr-old woman presented with lower, painless abdominal discomfort and a vacuolated mass measuring 12 cm on the right-hand side of the pelvis. She subsequently underwent a bilateral salpingo-oophorectomy. An osseous lesion was identified in the left ovary, which was hard in consistency and was associated with a multicystic complex lesion. Microscopic examination of the left ovary showed clusters of serous cells with moderate atypia, surrounded by a desmoplastic stroma with large areas of bone matrix. To the best of our knowledge, this is the first reported case of low-grade serous carcinoma with osseous metaplasia and a BRAF mutation.
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spelling pubmed-83606592021-08-18 Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma With a BRAF Mutation: A Case Report Catteau, Xavier Preat, Fanny D’haene, Nicky Noël, Jean-Christophe Int J Gynecol Pathol Pathology of the Upper Tract: Case Reports A 44-yr-old woman presented with lower, painless abdominal discomfort and a vacuolated mass measuring 12 cm on the right-hand side of the pelvis. She subsequently underwent a bilateral salpingo-oophorectomy. An osseous lesion was identified in the left ovary, which was hard in consistency and was associated with a multicystic complex lesion. Microscopic examination of the left ovary showed clusters of serous cells with moderate atypia, surrounded by a desmoplastic stroma with large areas of bone matrix. To the best of our knowledge, this is the first reported case of low-grade serous carcinoma with osseous metaplasia and a BRAF mutation. Lippincott Williams & Wilkins 2021-09 2020-11-25 /pmc/articles/PMC8360659/ /pubmed/33252399 http://dx.doi.org/10.1097/PGP.0000000000000732 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc.on behalf of the International Society of Gynecological Pathologists. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology of the Upper Tract: Case Reports
Catteau, Xavier
Preat, Fanny
D’haene, Nicky
Noël, Jean-Christophe
Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma With a BRAF Mutation: A Case Report
title Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma With a BRAF Mutation: A Case Report
title_full Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma With a BRAF Mutation: A Case Report
title_fullStr Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma With a BRAF Mutation: A Case Report
title_full_unstemmed Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma With a BRAF Mutation: A Case Report
title_short Osseous Metaplasia in Low-grade Ovarian Serous Carcinoma With a BRAF Mutation: A Case Report
title_sort osseous metaplasia in low-grade ovarian serous carcinoma with a braf mutation: a case report
topic Pathology of the Upper Tract: Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360659/
https://www.ncbi.nlm.nih.gov/pubmed/33252399
http://dx.doi.org/10.1097/PGP.0000000000000732
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