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Hypoxia-Inducible Factor-1α in Macrophages, but Not in Neutrophils, Is Important for Host Defense during Klebsiella pneumoniae-Induced Pneumosepsis

Hypoxia-inducible factor- (HIF-) 1α has been implicated in the ability of cells to adapt to alterations in oxygen levels. Bacterial stimuli can induce HIF1α in immune cells, including those of myeloid origin. We here determined the role of myeloid cell HIF1α in the host response during pneumonia and...

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Detalles Bibliográficos
Autores principales:	Otto, Natasja A., Pereverzeva, Liza, Leopold, Valentine, Ramirez-Moral, Ivan, Roelofs, Joris J. T. H., van Heijst, Jeroen W. J., de Vos, Alex F., van der Poll, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360744/ https://www.ncbi.nlm.nih.gov/pubmed/34393650 http://dx.doi.org/10.1155/2021/9958281

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